Publications by authors named "Jeffery L Wrana"
Article Synopsis
- Ultra-high dose rate FLASH radiotherapy shows promise in reducing toxicity to normal tissues compared to standard proton radiotherapy while maintaining effective anti-tumor responses.
- Research demonstrated that FLASH treatment led to faster recovery and improved survival in mice after whole-abdomen irradiation, linked to enhanced proliferation of stem and progenitor cells for tissue regeneration.
- The benefits of FLASH are attributed to changes in immune and stromal cell signaling, particularly involving TGF-β and IFN-I pathways, which differ significantly from those activated in standard radiotherapy, thus minimizing side effects.
Treatment regimens for acute myeloid leukemia (AML) continue to offer weak clinical outcomes. Through a high-throughput cell-based screen, we identified avocatin B, a lipid derived from avocado fruit, as a novel compound with cytotoxic activity in AML. Avocatin B reduced human primary AML cell viability without effect on normal peripheral blood stem cells.
View Article and Find Full Text PDFThe oncogene c-maf is frequently overexpressed in multiple myeloma cell lines and patient samples and contributes to increased cellular proliferation in part by inducing cyclin D2 expression. To identify regulators of c-maf, we developed a chemical screen in NIH3T3 cells stably overexpressing c-maf and the cyclin D2 promoter driving luciferase. From a screen of 2400 off-patent drugs and chemicals, we identified glucocorticoids as c-maf-dependent inhibitors of cyclin D2 transactivation.
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