Publications by authors named "Jeffery Johnston"
Article Synopsis
- Chronic inflammation in gastrointestinal tissues leads to disorders like Crohn's disease and ulcerative colitis, causing significant symptoms and tissue damage.
- The study analyzed blood samples from patients with various gastrointestinal conditions to explore gene expression changes, using advanced techniques like single-cell RNA-sequencing.
- Researchers found 730 genes with altered expression patterns, indicating both shared and unique inflammatory responses among the different disorders, which may aid in diagnosis and understanding of these conditions.
A cytomics-on-a-chip platform and diagnostic model stratifies risk for oral lichenoid conditions.
Oral Surg Oral Med Oral Pathol Oral Radiol
July 2024
Objective: A small fraction of oral lichenoid conditions (OLC) have potential for malignant transformation. Distinguishing OLCs from other oral potentially malignant disorders (OPMDs) can help prevent unnecessary concern or testing, but accurate identification by nonexpert clinicians is challenging due to overlapping clinical features. In this study, the authors developed a 'cytomics-on-a-chip' tool and integrated predictive model for aiding the identification of OLCs.
View Article and Find Full Text PDFBackground: To investigate the pro-inflammatory cytokine profiles in patients with or without cardiovascular disease (CVD) and with or without peri-implantitis.
Methods: Serum, peri-implant crevicular fluid (PICF), and gingival crevicular fluid (GCF) were collected from patients with (n = 82) or without CVD (n = 46) at the most severe peri-implantitis site including sites with periodontitis. A panel of proinflammatory molecules including high-sensitivity C-reactive protein (hsCRP), fibrinogen, interleukin-1 beta (IL-1β), IL-6, plasma tumor necrosis factor-alpha (TNF-α), matrix metallo-proteinase-8 (MMP-8), osteoprotegerin (OPG), vascular endothelial growth factor (VEGF), IL-17, IL-8, tissue inhibitor of metalloproteinase-2 (TIMP-2), myeloperoxidase (MPO), and prostaglandin E (PGE ) were analyzed using human custom Quantibody arrays.
Background: This study assesses the association between peri-implantitis and cardiovascular diseases (CVD).
Methods: One hundred and twenty-eight patients with dental implants were recruited to evaluate the prevalence of peri-implantitis in patients with or without CVD (CVD group, n = 82, control group, n = 46, respectively). Diagnosis of peri-implantitis followed the 2017 World Workshop guidelines and the severity was defined as mild, moderate, and severe form when the radiographic bone loss (RBL) was <2, 2 to 4, and >4 mm.