Breast Metastasis From Colorectal Carcinoma Identified by Gene Assay: Case Report and Review of Literature.

Colon cancer metastasis to the breast is a rare presentation and has a poor prognosis. Diagnosis of the primary site for the metastasis is usually aided by immunohistochemistry but can be non-conclusive. Gene expression assay can be helpful in diagnosing the primary cancer site.

Hypocalcemia in a Patient With Metastatic Prostate Cancer From Denosumab Treatment.

Denosumab is a humanized monoclonal antibody that binds RANKL to inhibit osteoclast activity. It is indicated for the prevention of skeletal-related events (SRE) in patients with solid tumors who have bone metastasis and in patients with multiple myeloma. Hypocalcemia is one of the known side effects of denosumab, which can be prevented with calcium supplementation.

Viable circulating tumor cell enrichment by flexible micro spring array.

We demonstrated a high throughput versatile platform capable of isolating circulating tumor cells (CTCs) from clinically relevant volumes of blood while preserving their viability and ability to proliferate. The enrichment is based on the fact that CTCs are larger compared with normal blood cells. The incorporated system allows size-based separation of CTCs at the micro-scale, while taking advantage of a high throughput and rapid processing speed.