Publications by authors named "Jefferson Proano Zamudio"

Background: Intraoperative adverse events (iAEs) during general surgery can lead to significant morbidity and healthcare burden, yet their impact remains underexplored. We aimed to estimate the nationwide incidence of iAEs in general surgery and explore their associations with mortality, complications, length of stay, and costs.

Methods: We conducted a retrospective cohort study using the Nationwide Readmissions Database 2019 and included adult patients (aged 18 years and older) who underwent general surgical procedures.

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Introduction: Racial and ethnic disparities in emergency general surgery (EGS) patients have been well described in the literature. Nonetheless, the burden of these disparities, specifically within the more vulnerable older adult population, is relatively unknown. This study aims to investigate racial and ethnic disparities in clinical outcomes among older adult patients undergoing EGS.

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Article Synopsis
  • Care fragmentation in elderly patients post-hospital discharge is linked to higher morbidity and mortality, necessitating a study to identify contributing factors and their relation to mortality rates.
  • A retrospective analysis of over 447,000 patients showed that 24.3% faced unplanned readmissions within 90 days, with 20.8% experiencing care fragmentation, particularly among older females.
  • Factors like living in rural areas, low-income neighborhoods, and specific discharge decisions significantly predicted care fragmentation, which correlates with increased mortality rates in this population.
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Background: The impact of COVID-19 infection at the time of traumatic injury remains understudied. Previous studies demonstrate that the rate of COVID-19 vaccination among trauma patients remains lower than in the general population. This study aims to understand the impact of concomitant COVID-19 infection on outcomes in trauma patients.

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  • About 61 million people in the U.S. have a disability, but not much is known about how this affects their hospital care after surgery.
  • The study looked at over 378,000 patients who had emergency surgeries and compared those with disabilities to those without, finding that disabled patients had more health issues afterward.
  • It showed that disabled patients had a higher chance of returning to the hospital within 30 days, suffered more complications, and stayed in the hospital longer than those without disabilities.
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Background: Despite the high prevalence of disability conditions in the US, their association with access to minimally invasive surgery (MIS) remains under-characterized.

Objective: To understand the association of disability conditions with rates of MIS and describe nationwide temporal trends in MIS in patients with disability conditions.

Methods: We conducted a retrospective cohort study using the Nationwide Readmission Database (2016-2019).

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  • This study investigated if lower extremity amputation in civilian injuries increases the risk of venous thromboembolism (VTE), specifically pulmonary embolism (PE) and deep vein thrombosis (DVT).
  • Researchers analyzed data from over 145,000 patients with severe leg injuries, comparing those who underwent amputation with those who had limb salvage.
  • Findings showed that amputee patients had significantly higher rates of both PE (4.2% vs. 2.5%) and DVT (6.5% vs. 3.4%), highlighting the increased risk of VTE after traumatic limb loss.
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  • TEVAR (thoracic endovascular aortic repair) is being increasingly used to treat blunt thoracic aortic injury (BTAI), but there is limited research on what happens to patients after they leave the hospital.
  • A study analyzed over 2,000 patients who underwent TEVAR for BTAI, finding that 13% were readmitted within 90 days, mainly due to reasons like sepsis and wound complications.
  • The readmission rate for BTAI patients was significantly lower compared to those treated for acute type B aortic dissections, suggesting different recovery profiles for trauma-related versus non-traumatic vascular conditions.
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Background: Recent literature has shown that surgical stabilization of rib fractures benefits patients with rib fractures accompanied by pulmonary contusion; however, the impact of timing on surgical stabilization of rib fractures in this patient population remains unexplored. We aimed to compare early versus late surgical stabilization of rib fractures in patients with traumatic rib fractures and concurrent pulmonary contusion.

Methods: We selected all adult patients with isolated blunt chest trauma, multiple rib fractures, and pulmonary contusion undergoing early (<72 hours) versus late surgical stabilization of rib fractures (≥72 hours) using the American College of Surgeons Trauma Quality Improvement Program 2016 to 2020.

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Introduction: the ability of the care team to reliably predict postoperative risk is essential for improvements in surgical decision-making, patient and family counseling, and resource allocation in hospitals. The Artificial Intelligence (AI)-powered POTTER (Predictive Optimal Trees in Emergency Surgery Risk) calculator represents a user-friendly interface and has since been downloaded in its iPhone and Android format by thousands of surgeons worldwide. It was originally developed to be used in non-traumatic emergency surgery patients.

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More than 20% of the population in the United States suffers from a disability, yet the impact of disability on post-operative outcomes remains understudied. This analysis aims to characterize post-operative infectious complications in patients with disability. This was a retrospective review of the National Readmission Database (2019) among patients undergoing common general surgery procedures.

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Infectious complications lead to worse post-operative outcomes and are used to compare hospital performance in pay-for-performance programs. However, the impact of social and behavioral determinants of health on infectious complication rates after emergency general surgery (EGS) remains unclear. All patients undergoing EGS in the 2019 Nationwide Readmissions Database were included.

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Background: Surgical site infections (SSI) are a common complication of laparotomy incisions. The role of Negative Pressure Wound Therapy (NPWT) in preventing SSIs has not yet been explored in a nationwide analysis. We aimed to evaluate the association of the prophylactic use of NPWT with SSIs in patients undergoing an emergency laparotomy procedure.

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  • Rib fractures are common injuries that can lead to complications like delayed hemothorax (DHTX), which affects 10-37% of patients and involves blood accumulation in the pleural cavity after injury.
  • A study using the National Readmission Database examined 242,071 patients with blunt rib fractures, finding that 635 had DHTX readmissions within 30 days, with previous hemothorax diagnosis being a significant risk factor for readmission.
  • While DHTX readmissions are relatively rare, they can lead to serious complications like respiratory failure and infections, highlighting the need for more research to identify and address the risk factors involved.
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Background: Early surgical stabilization of rib fractures (SSRF) is associated with improved inpatient outcomes in patients with multiple rib fractures. However, there is still a paucity of data examining the optimal timing of SSRF in patients with concomitant traumatic brain injury (TBI). This study aimed to assess whether earlier SSRF was associated with improved outcomes in patients with multiple rib fractures and TBI.

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Introduction: Access to postacute care services in rehabilitation or skilled nursing facilities is essential to return trauma patients to their preinjury functional level but is often hindered by systemic barriers. We sought to study the association between the type of insurance, socioeconomic status (SES) measures, and postacute care utilization after injury.

Methods: Adult trauma patients with an Injury Severity Score (ISS) ≥9 admitted to one of three Level I trauma centers were contacted 6-12 mo after injury to gather long-term functional and patient-centered outcome measures.

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Introduction: Current guidelines for retained hemothorax (rHTX) in trauma patients recommend video-assisted thoracic surgery (VATS) within 4 days. However, this recommendation is currently based upon evidence from small observational studies. The aim of this study is to further evaluate the association between timing of VATS and clinical outcomes in rHTX following trauma.

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Background: Rib fractures represent a typical injury pattern in older people and are associated with respiratory morbidity and mortality. Regional analgesia modalities are adjuncts for pain management, but the optimal timing for their initiation remains understudied. We hypothesized that early regional analgesia would have similar outcomes to late regional analgesia.

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Introduction: The usage of extracorporeal membrane oxygenation (ECMO) in trauma patients has increased significantly within the past decade. Despite increased research on ECMO application in trauma patients, there remains limited data on factors predicting morbidity and mortality outcome. Therefore, the primary objective of this study is to describe patient characteristics that are independently associated with mortality in ECMO therapy in trauma patients, to further guide future research.

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Background: Patient-reported outcomes of postdischarge functional status can provide insight into patient recovery experiences not typically reflected in trauma registries. Injuries may be characterized by a long-term loss of independence. We sought to examine factors predictive of patient-reported, postdischarge loss of independence in trauma patients.

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Article Synopsis
  • Patients undergoing lower limb amputation after trauma have a high risk of venous thromboembolism (VTE), leading to a debate on the best medication for prevention.
  • Researchers analyzed data from over 4,100 trauma patients who received either unfractionated heparin or low-molecular-weight heparin to see which was more effective at preventing VTE.
  • The study concluded that low-molecular-weight heparin significantly reduced the rates of VTE compared to unfractionated heparin, making it the better choice for thromboprophylaxis in this patient group.
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  • Traumatic brain injury (TBI) is traditionally seen as a reason to avoid surgical stabilization of rib fractures (SSRF), but this study investigates whether SSRF could actually improve outcomes compared to non-surgical management.
  • An analysis of over 36,000 patients showed that those receiving SSRF had lower mortality rates and longer hospital stays, with significant differences noted for both mild and severe TBI cases.
  • The findings suggest that SSRF may be beneficial for TBI patients with rib fractures, leading to better survival rates despite increased lengths of hospital and ICU stays.
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Introduction: The American Association for the Surgery of Trauma Colon Organ Injury Scale (OIS) was updated in 2020 to include a separate OIS for penetrating colon injuries and included imaging criteria. In this multicenter study, we describe the contemporary management and outcomes of penetrating colon injuries and hypothesize that the 2020 OIS system correlates with operative management, complications, and outcomes.

Methods: This was a retrospective study of patients presenting to 12 Level 1 trauma centers between 2016 and 2020 with penetrating colon injuries and Abbreviated Injury Scale score of <3 in other body regions.

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  • Patients undergoing surgery with perioperative COVID-19 had worse postoperative outcomes compared to those without COVID-19, indicating the potential severity of the virus in surgical settings.
  • A study matched 1,054 patients with perioperative COVID-19 to 96,882 patients without it, focusing on demographics and health conditions to ensure comparable results.
  • After matching, COVID-19 patients experienced higher mortality (12% vs. 8.1%), longer hospital stays, and more complications such as renal failure and sepsis, while having lower rates of bleeding compared to non-COVID patients.
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Background: Tiered trauma triage systems have resulted in a significant mortality reduction, but models have remained unchanged. The aim of this study was to develop and test an artificial intelligence algorithm to predict critical care resource utilization.

Methods: We queried the ACS-TQIP 2017-18 database for truncal gunshot wounds(GSW).

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