Publications by authors named "Jeff T Roesgen"
Article Synopsis
- The study focuses on the development of new compounds called N-sulfonyl-2-indole carboxamides that interact with PPAR-gamma, a receptor important for various biological functions.
- Through chemical optimization, a specific compound named 4q was found to have a strong binding affinity to PPAR-gamma, with an IC(50) value of 50 nM, indicating its potential effectiveness.
- Initial tests in cells suggest that these compounds could be useful in treating osteoporosis, a condition characterized by weak and brittle bones.
As higher density formats become more and more common in HTS labs, the expectations for maintaining faster, lower cost screens puts great pressure on traditional 96-well screens. In some cases higher density formats are not compatible with the assay. This seems especially true in cell-based assays.
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