Synopsis of recent research by authors named "Jeff P Holden"
- Jeff P Holden's research primarily focuses on the pharmacokinetics of antimicrobial agents, specifically cefazolin, during various surgical procedures, particularly in the context of cardiovascular surgery.
- His study investigates how different surgical conditions, including the use of cardiopulmonary bypass and profound hypothermic circulatory arrest, impact plasma levels of cefazolin, which is crucial for effective antimicrobial prophylaxis.
- The findings suggest that cardiopulmonary bypass duration and hypothermic conditions significantly alter cefazolin levels, which may influence infection rates and surgical outcomes, highlighting the need for tailored antibiotic dosing in surgical settings.
