A comparative study of automatic image segmentation algorithms for target tracking in MR-IGRT.

On-board magnetic resonance (MR) image guidance during radiation therapy offers the potential for more accurate treatment delivery. To utilize the real-time image information, a crucial prerequisite is the ability to successfully segment and track regions of interest (ROI). The purpose of this work is to evaluate the performance of different segmentation algorithms using motion images (4 frames per second) acquired using a MR image-guided radiotherapy (MR-IGRT) system.

Quality of Intensity Modulated Radiation Therapy Treatment Plans Using a ⁶⁰Co Magnetic Resonance Image Guidance Radiation Therapy System.

Purpose: This work describes a commercial treatment planning system, its technical features, and its capabilities for creating (60)Co intensity modulated radiation therapy (IMRT) treatment plans for a magnetic resonance image guidance radiation therapy (MR-IGRT) system.

Methods And Materials: The ViewRay treatment planning system (Oakwood Village, OH) was used to create (60)Co IMRT treatment plans for 33 cancer patients with disease in the abdominal, pelvic, thorax, and head and neck regions using physician-specified patient-specific target coverage and organ at risk (OAR) objectives. Backup plans using a third-party linear accelerator (linac)-based planning system were also created.

A safety run-in and randomized phase 2 study of cilengitide combined with chemoradiation for newly diagnosed glioblastoma (NABTT 0306).

Background: Cilengitide is a selective integrin inhibitor that is well tolerated and has demonstrated biologic activity in patients with recurrent malignant glioma. The primary objectives of this randomized phase 2 trial were to determine the safety and efficacy of cilengitide when combined with radiation and temozolomide for patients with newly diagnosed glioblastoma multiforme and to select a dose for comparative clinical testing.

Methods: In total, 112 patients were accrued.

Control of overwintering filbertworm (Lepidoptera: Tortricidae) larvae with Steinernema carpocapsae.

Filbertworm, Cydia latiferreana (Walsingham) (Lepidoptera: Tortricidae), is a key insect pest associated with hazelnuts, Corylus avellana L. (Fagales: Betulaceae), in North America. This study investigated the feasibility of entomopathogenic nematodes as an alternative strategy for filbertworm control.

Breadboard testing of a phase-conjugate engine with an interferometric wave-front sensor and a microelectromechanical systems-based spatial light modulator.

Laboratory breadboard results of a high-speed adaptive-optics system are presented. The wave-front sensor for the adaptive-optics system is based on a quadrature interferometer, which directly measures the turbulence-induced phase aberrations. The spatial light modulator used in the phase-conjugate engine was a microelectromechanical systems-based piston-only correction device with 1024 actuators.