Publications by authors named "Jeff N Rottman"

Article Synopsis
  • Emery-Dreifuss muscular dystrophy (EDMD1) is linked to mutations in the emerin gene (X-linked) or the lamin A/C gene (autosomal), prompting research to create a mouse model lacking emerin.
  • Although these emerin-null mice show no major physical issues, their muscle regeneration exhibits defects, especially in cell cycle processes and delayed muscle cell differentiation linked to transcription factors Rb1 and MyoD.
  • In contrast to the emerin-null mice, mice lacking lamin A/C (Lmna null) did not show the same transcriptional pathway disruptions, suggesting that different mutations might influence muscle cell behavior in distinct ways in muscle pathologies.
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