Publications by authors named "Jeff Lung-Fa Kao"
Article Synopsis
- The study focuses on the cell walls of certain bacteria, including a pathogenic strain, highlighting a previously unreported family of lipopeptides.
- Researchers utilized advanced techniques like linear ion-trap mass spectrometry, NMR spectroscopy, and GC/MS to determine the structures of these lipopeptides, revealing key aspects such as peptide sequences and fatty acyl substitutions.
- A major lipopeptide was identified along with its unique structural features, but tests indicated that these new compounds did not show antibiotic activity against several tested microorganisms.
Nucleoside analogues, such as penciclovir, ganciclovir, acyclovir, and their fluoro-substituted derivatives, have wide utility as antivirals. Among these analogues, FHBG ((18)F-Fluorohydroxybutylguanine) is a well-validated PET (positron emission tomography) probe for monitoring reporter gene expression. To evaluate whether or not imposing rigidity into the flexible side chain of FHBG 4 could also impact its interaction, with amino acid residues within the binding site of HSV1-TK (Herpes Simplex Virus-1 Thymidine Kinase), thus influencing its cytotoxic activity.
View Article and Find Full Text PDFCis-syn thymine dimers are the major photoproducts of DNA and are the principal cause of mutations induced by sunlight. To better understand the nature of base pairing with cis-syn thymine dimers, we have synthesized a decamer oligodeoxynucleotide (ODN) containing a cis-syn thymine dimer labeled at the N3 of both T's with 15N by two efficient routes from [3-15N]-thymidine phosphoramidite. In the postsynthetic irradiation route, an ODN containing an adjacent pair of [3-15N]-labeled T's was irradiated and the cis-syn dimer-containing ODN isolated by HPLC.
View Article and Find Full Text PDF