Publications by authors named "Jeff Kroetsch"
Article Synopsis
- L-tryptophan (L-W) is a precursor for a vasoconstrictor, yet its ethyl ester form (L-Wee) lowers blood pressure; the study aims to understand the mechanisms behind this effect.
- Experiments on male rats reveal that L-Wee significantly decreases mean arterial pressure and heart rate in a dose-dependent manner, unlike L-W, and impacts vascular contraction responses.
- L-Wee's effects are attributed to its blockade of voltage-operated calcium channels in vascular smooth muscle cells, suggesting it specifically relaxes smaller blood vessels.
