Publications by authors named "Jeff Dage"
Article Synopsis
- A study compared blood plasma phosphorylated tau levels in Alzheimer’s disease (AD) patients versus non-AD patients to assess different immunoassays and their accuracy in detecting AD.* -
- Results showed that plasma tau levels were significantly higher in the AD group, with the Janssen p-tau217 demonstrating the highest accuracy for identifying abnormal Aβ42/p-tau ratios.* -
- The study suggests that certain plasma p-tau biomarkers can effectively function as standalone indicators for diagnosing biologically-defined AD in memory clinics.*
In this study, the retention behaviors of pharmaceutical and drug-like compounds in supercritical fluid chromatography (SFC) with polar stationary phases were evaluated using linear solvation energy relationships (LSERs). We used more than 200 compounds, including mono-, di-substituted benzenes, and other marketed drugs with a wide range of solvation descriptors. The dominant contribution to positive retention was the hydrogen bond donor acidity of the solutes, particularly for pyridine and amino columns.
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