Relative bioavailability of orally administered fosphenytoin sodium injection compared with phenytoin sodium injection in healthy volunteers.

Study Objective: To describe the pharmacokinetics of fosphenytoin (FPHT) sodium injection when administered orally, and to determine the relative oral bioavailability (FREL ) of FPHT sodium injection compared with PHT sodium injection based on pharmacokinetic modeling in healthy volunteers.

Design: Open-label, randomized, single-dose, two-period, two-sequence crossover study.

Setting: University-affiliated clinical research center funded by the National Center of Research Resources.