Publications by authors named "Jeff Clogston"
Article Synopsis
- Researchers developed a novel delivery system for siRNA using light-activated polyplexes to improve RNA interference therapy's effectiveness.
- The system combines sulfonated polyethylenimine with a photoactivatable component for controlled endosomal escape, which led to gene knock-down in cancer cells upon laser activation.
- While the sulfonated version needed light to function, the non-sulfonated version worked without additional treatment, suggesting different mechanisms of cellular release for the two approaches.
