Preventing early, prolonged vitamin E deficiency: an opportunity for better cognitive outcomes via early diagnosis through neonatal screening.

Objective: To evaluate whether early diagnosis of cystic fibrosis (CF) through newborn screening (NBS) and early vitamin E status are associated with cognitive function.

Study Design: We assessed cognitive function for 71 children without meconium ileus (ages 7.3-16.

Cognitive function of children with cystic fibrosis: deleterious effect of early malnutrition.

Objective: Patients who have cystic fibrosis (CF) and experience delayed diagnosis by traditional methods have greater nutritional insult compared with peers diagnosed via neonatal screening. The objective of this study was to evaluate cognitive function in children with CF and the influence of both early diagnosis through neonatal screening and the potential effect of early malnutrition.

Methods: Cognitive assessment data were obtained for 89 CF patients (aged 7.