Publications by authors named "Jeferson de Jesus Aranha"
DO THE IMMUNOSUPPRESSIVE DRUGS AFFECT THE HYPOTHALAMIC NUCLEI INVOLVED IN THE REGULATION OF FOOD INTAKE? AN EXPERIMENTAL STUDY.
Rodrigo Schuh Djanira Aparecida da Luz Veronez Eduardo José Brommelstroet Ramos Flávia Dorieux Wastner Cunha Mattheus Lopes Pereira Jeferson de Jesus Aranha Marcelo Alves Aranha
Arq Bras Cir Dig
September 2023
Article Synopsis
- Immunosuppressive drugs, crucial for preventing organ rejection in transplant patients, may cause unknown side effects on the brain areas regulating appetite and weight gain.
- A study on Wistar rats compared the effects of two immunosuppressive treatments (tacrolimus and mycophenolate mofetil) over 14 weeks, observing their impact on hypothalamic nuclei related to food intake.
- Results indicated that while all rats gained weight, there were no significant changes in neuronal density or morphology in the hypothalamic regions, suggesting that the drugs did not alter these specific brain aspects.