Bone density and quality in patients treated with direct-acting oral anticoagulants versus warfarin.

Introduction: Direct-acting oral anticoagulants (DOACs) are therapeutic alternatives to warfarin that act independently of vitamin K, thus not affecting bone matrix formation. The aim of this study was to compare bone mineral density (BMD) and microarchitecture in patients treated with DOACs versus warfarin.

Methods: Cross-sectional, observational study in patients using oral anticoagulants for >1 year and a paired control group (CG).

Trabecular bone score (TBS) and bone mineral density in patients with long-term therapy with warfarin.

Unlabelled: In this study, we compared patients using the anticoagulant warfarin for more than a year with a control group with similar characteristics but without using the drug. We demonstrated worse BMD and bone quality by trabecular bone score (TBS) in patients using warfarin for more than 1 year.

Purpose: Evaluate the bone mineral density (BMD) and the trabecular bone score (TBS) of patients taking warfarin for more than 1 year compared with a control group.