Publications by authors named "Jeferson D da Silva"
Vitamin A (retinol) is involved in signaling pathways regulating gene expression and was postulated to be a major antioxidant and anti-inflammatory compound of the diet. Parkinson's disease (PD) is a progressive neurodegenerative disorder, characterized by loss of nigral dopaminergic neurons, involving oxidative stress and pro-inflammatory activation. The aim of the present study was to evaluate the neuroprotective effects of retinol oral supplementation against 6-hydroxydopamine (6-OHDA, 12 μg per rat) nigrostriatal dopaminergic denervation in Wistar rats.
View Article and Find Full Text PDFRetinoids (vitamin A and derivatives) are recognized as essential factors for central nervous system (CNS) development. Retinol (vitamin A) also was postulated to be a major antioxidant component of diet as it modulates reactive species (RS) production and oxidative stress in biological systems. Oxidative stress plays a major role either in pathogenesis or development of neurodegenerative diseases, or even in both.
View Article and Find Full Text PDFArticle Synopsis
- A study on 40 trained marathon runners explored the impact of different exercise volumes (higher-volume vs. lower-volume) on inflammatory, redox, and hormonal responses.
- At rest, lower-volume group showed higher levels of inflammatory markers and lower antioxidant activity compared to the higher-volume group.
- During exercise, both groups experienced similar reductions in TNF-α but different increases in CRP, indicating varying inflammatory responses, while antioxidants decreased in both groups but at different rates.
- Overall, the findings suggest that a higher training volume is linked to better inflammatory and redox profiles, possibly due to reduced inflammatory responses to acute exercise.