Modernizing load and emission factors for construction machinery based on real-world operation: Estimation of emission data in Korea.

The emissions inventory for non-road mobile machinery (NRMM) in Korea relies on laboratory engine tests, which do not accurately reflect the real-world emissions from construction machinery. Hence, standardized real-world test conditions suitable for the Korean environment were first designed based on the manufacturer's testing methods and previous research. Next, using portable emissions measurement systems (PEMS), data on exhaust emissions and load factor (LF) were collected and analyzed during real-world tests on three types of construction machinery (excavators, loaders, and forklifts) with high registration rates and emissions in Korean environment.

A homozygous exonic variant leading to exon skipping in ABCC8 as the cause of severe congenital hyperinsulinism.

Congenital hyperinsulinism (CHI) is genetically heterogeneous, caused by pathogenic variants in multiple known genes regulating insulin secretion from the pancreatic β-cells. The ABCC8 gene encodes the sulfonylurea receptor 1 (SUR1), a key player in insulin secretion, and pathogenic variants in ABCC8 are the most common cause of CHI. With increased application of genetic testing in clinical practice, variants of unknown clinical significance (VUS) are commonly reported.

Role of glucagon-like peptide-1 in the pathogenesis and treatment of diabetes mellitus.

Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted from enteroendocrine L cells in response to ingested nutrients. The first recognized and most important action of GLP-1 is the potentiation of glucose-stimulated insulin secretion in beta-cells, mediated by activation of its seven transmembrane domain G-protein-coupled receptor. In addition to its insulinotropic actions, GLP-1 exerts islet-trophic effects by stimulating replication and differentiation and by decreasing apoptosis of beta-cells.