Anticandidal Effect of New Imidazole Derivatives Over Aspartic Protease Inhibition.

Candidiasis is one of the most serious microbial infections in the world. One of the main virulence factors for Candida albicans is the crucial secretion of aspartic proteases (Saps). Saps are hydrolytic enzymes that play a major role in many fungal pathophysiological processes as well as in many levels of the associations between the fungus and its host.

Artificial Intelligence: A Reliable Tool to Detect the Elongation of the Styloid Process.

Background Eagle's syndrome is characterized by the anomalous elongation of the styloid process. This condition is usually identified through the manual evaluation of orthopantomogram (OPG) images, which is time-consuming and can have interobserver variability. The application of Artificial intelligence (AI) in radiology is gaining importance and interest in recent years.

Peptidomimetics for CVD screened via TRADD-TRAF2 complex interface assessments.

The main aim of this study is to screen and develop Peptidomimetics to treat atherosclerosis (AS) which is a Cardio Vascular Disease (CVD). Peptidomimetics were obtained from the protein-protein interaction interface of TRADD (Tumor necrosis factor receptor type 1-associated DEATH domain protein) and TRAF2 (TNF receptor-associated factor 2) complex. TRADD-TRAF2 interaction is critical in AS pathogenesis since it assists a series of signal transducers that activate NF-κB.

Validated Identity Test Method for NHPs Using DNA-Based Species-Specific Hydrolysis PCR Probe.

There is considerable risk of adulteration of herbal products in the natural health product (NHP) industry. Authentication of products is challenging because of the standard, complex, analytical chemistry methods that may be too costly and not appropriate for both raw and finished products. We sought to develop and validate an alternative method to authenticate herbal dietary supplements, based on the use of a species-specific hydrolysis PCR probe assay.

Relationship between Antioxidant Properties and Chemical Composition of Abutilon Indicum Linn.

Aim of this paper is to find out the relationship between antioxidant activity of Abutilon indicum Linn and their phytochemical composition especially phenols and flavonols. Successive extractions were carried out for the Abutilon indicum plant with petroleum ether, chloroform, ethyl acetate, n-butanol, ethanol and water. All these extracts were evaluated for their antioxidant activities.