Publications by authors named "Jeevan Patra"
Article Synopsis
- The study investigates dual inhibitors of falcipains FP-2 and FP-3, which show potential toxicity due to similar binding affinities with human cathepsins.
- Researchers aim to enhance the selectivity of these inhibitors by designing new analogs that interact better with falcipains and less with human cathepsins.
- Molecular dynamics simulations reveal that the newly designed analogs exhibit improved binding affinities and selectivity towards falcipains, reducing the risk of toxicity.
Article Synopsis
- Malaria, caused by Plasmodium species, poses a serious health threat in tropical regions, with increasing resistance to existing treatments prompting the need for new drug development.
- Falcipains, a group of cysteine proteases that play a key role in the parasite's heme metabolism during its life cycle in red blood cells, have been identified as promising targets for new therapies.
- This discussion reviews the biology and chemistry of falcipains, highlighting efforts to create effective inhibitors and examining why some compounds succeed while others fail in targeting these important proteins for antimalarial treatment.
As acetylcholinesterase (AChE) plays a crucial role in advancing Alzheimer's disease (AD), its inhibition is a promising approach for treating AD. Sulindac is an NSAID of the aryl alkanoic acid class, consisting of a indene moiety, which showed neuroprotective behavior in recent studies. In this study, newer Indene analogs were synthesized and evaluated for their in vitro AChE inhibition.
View Article and Find Full Text PDFUnderstanding the autistic brain and the involvement of genetic, non-genetic, and numerous signaling pathways in the etiology and pathophysiology of autism spectrum disorder (ASD) is complex, as is evident from various studies. Apart from multiple developmental disorders of the brain, autistic subjects show a few characteristics like impairment in social communications related to repetitive, restricted, or stereotypical behavior, which suggests alterations in neuronal circuits caused by defects in various signaling pathways during embryogenesis. Most of the research studies on ASD subjects and genetic models revealed the involvement of mutated genes with alterations of numerous signaling pathways like Wnt, hedgehog, and Retinoic Acid (RA).
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