Harmine-loaded galactosylated pluronic F68-gelucire 44/14 mixed micelles for liver targeting.

Harmine (HM), a phytoconstituent has wide range of pharmacological activities including antimicrobial, antifungal, antioxidative, and anticancer. HM has shown promising anticancer activity against liver cancer cells. However, poor aqueous solubility, multidrug pump P-gp efflux, extensive metabolism, and rapid elimination due to glucuronidation/sulfation limit clinical utility of HM.