Publications by authors named "Jeesu Min"
Article Synopsis
- Dapagliflozin, typically used for treating chronic kidney disease in adults, was studied in 22 children with kidney disease and proteinuria to evaluate its effects.
- The treatment lasted over 3 months, with children being around 15.6 years old, and all had prior treatment with specific kidney medications.
- Results showed no significant changes in kidney function or protein levels; however, there was a notable decrease in kidney function at the latest follow-up, indicating the need for further research to establish dapagliflozin's safety and effectiveness in this age group.
Outcome of immunosuppression in children with IgA vasculitis-related nephritis.
Nephrol Dial Transplant
July 2024
Article Synopsis
- Immunoglobulin A vasculitis with nephritis (IgAVN) is the most common vasculitis in children, and this study aimed to analyze clinical outcomes, treatments, and risk factors in a large cohort of 1148 children diagnosed with the condition.
- The retrospective analysis revealed that poorer outcomes were associated with factors like older age, lower kidney function at onset, hypertension, and certain kidney damage features, but no specific treatment was found to be more effective than others.
- The study concluded that there is a need for further research and clinical trials to determine effective treatments and improve health outcomes for children with IgAVN.
Long-term outcomes and associated prognostic risk factors of childhood-onset lupus nephritis.
Kidney Res Clin Pract
December 2023
Article Synopsis
- This study focused on childhood-onset lupus nephritis (LN), examining the clinical features, kidney outcomes, and risk factors related to prognosis in 216 patients across South Korea.
- Most patients presented with nephrotic syndrome or hematuria, and the most common kidney damage was WHO class IV LN, with nearly 15% developing advanced chronic kidney disease (CKD) after an average follow-up of about 8 years.
- Key risk factors identified for advanced CKD included being male and not achieving remission within the first year of treatment, indicating the need for careful monitoring of these patients to improve their long-term outcomes.
Article Synopsis
- The study examined the long-term outcomes of nephrocalcinosis (NC) in preschool-age children and categorized them by etiology, revealing prematurity, tubular disorders, and other causes.
- Of the 67 children studied, most were asymptomatic at diagnosis, and a significant number had grade 3 NC, particularly among those with tubular disorders.
- Kidney function remained stable overall, but those whose NC grade didn't improve experienced a decline in kidney function, emphasizing the importance of early detection and grade monitoring.
The most common causes of short stature (SS) in children are familial short stature (FSS) and idiopathic short stature (ISS). Recently, growth plate dysfunction has been recognized as the genetic cause of FSS or ISS. The aim of this study was to investigate monogenic growth failure in patients with ISS and FSS.
View Article and Find Full Text PDFBackground: We aimed to investigate the efficacy and safety of repeated use of rituximab (RTX) in pediatric patients with nephrotic syndrome (NS).
Methods: Retrospective review of 50 patients with steroid-dependent NS (SDNS) who had received more than three cycles of RTX was conducted; each consisted of one to four infusions until B lymphocytes were depleted.
Results: The median age of starting the first RTX cycle was 12.
Single gene pathogenic mutations have been implicated in up to 30% of pediatric steroid-resistant nephrotic syndrome (SRNS) cases, mostly in infantile patients. Among them is , which has been recently discovered and encodes the laminin α5 chain. The laminin α5β2γ1 heterotrimer is an essential component of the glomerular basement membrane and is necessary for embryogenesis and immune modulation.
View Article and Find Full Text PDFBioimpedance spectroscopy (BIS) is a noninvasive method used to evaluate body fluid volume status in dialysis patients, but reports on its effectiveness in pediatrics are scarce. We investigated the correlation between BIS and clinical characteristics and identified the changes in patients whose dialysis prescription was modified based on BIS. The medical records of children on maintenance dialysis who had undergone BIS between 2017 and 2019 were reviewed.
View Article and Find Full Text PDFArticle Synopsis
- Renal tubular dysgenesis (RTD) is a rare, fatal disorder caused by poor development of kidney tubules, leading to complications such as oligohydramnios and characteristic physical deformities known as the Potter sequence.
- The case discussed involves a preterm boy who developed severe symptoms including anuria and hypotension, with imaging revealing kidney enlargement and bone structure issues, ultimately leading to death on day 23 of life.
- Genetic analysis confirmed RTD through the identification of specific pathogenic variations, suggesting clinicians should consider RTD in cases of severe oligohydramnios and persistent low blood pressure in newborns.