Importance: Considerable controversy exists regarding the best spontaneous breathing trial (SBT) technique to use.
Objective: To summarize trials comparing alternative SBTs.
Data Sources: Several databases (MEDLINE [from inception to February 2023], the Cochrane Central Register of Controlled Trials [in February 2023], and Embase [from inception to February 2023] and 5 conference proceedings (from January 1990 to April 2023) were searched in this systematic review and meta-analysis.