Publications by authors named "Jee Y Kim"

The CO adsorption capacity of biochar depends on the type of biomass used and its physicochemical properties; various sorption parameters including temperature, CO concentration, and humidity affect the CO adsorption capacity. Biochar derived from defatted black soldier fly larvae (BSFL) biomass was investigated for direct CO capture and exhibited a hydrophilic/mesoporous structure that contained high concentrations of alkali and alkaline metals (>10 wt%), which contribute to CO chemisorption. The CO adsorption efficiency was higher at 25 °C compared with that at 30 °C and 35 °C, probably due to reduced Brownian motion of CO molecules at lower temperatures.

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  • * A study introduced a new diagnostic method using circulating biomarkers, specifically analyzing breast cancer-derived extracellular vesicles (BEVs) to improve screening accuracy.
  • * Researchers identified a unique signature of five miRNAs that distinguished breast cancer patients from healthy individuals, revealing insights into tumor behavior and potential survival outcomes, paving the way for more personalized cancer treatment.
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  • HER2-targeted therapies are effective for HER2-positive breast cancer, and recent research shows that they can also help patients with low HER2 expression, making it essential to identify this subgroup.
  • The study suggests tumor-derived extracellular vesicles (TEVs) could serve as diagnostic tools to reflect HER2 status, validated through tests on breast cancer cell lines and patient plasma samples.
  • The method showed promise in distinguishing HER2-negative from HER2-low patients, achieving a sensitivity of 53.8% and perfect specificity, highlighting the need for more research in this area.
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Crystal facet engineering has emerged as a promising approach to enhance photocatalytic activity of semiconductors by preferentially accumulating charge carriers (electrons and holes) on specific facets. This facilitates efficient electron and hole transfer across the semiconductor/cocatalyst interface, enabling their transport to the cocatalyst surface for redox reactions. In this study, three Cu-doped TiO nanorods with small, medium, and large ratios of reductive {110} to oxidative {111} facets were synthesized (namely Cu-TiO-SR, Cu-TiO-MR, and Cu-TiO-LR, respectively).

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  • The study highlights the urgent need for sustainable organic waste management due to rising waste generation globally.
  • It investigates converting organic waste from the animal feed industry into biodiesel and syngas, finding that non-catalytic transesterification is more effective than acid-catalysed methods for biodiesel production.
  • The research further demonstrates that using a nickel-impregnated catalyst in pyrolysis significantly increases gas yield, enhancing the renewable energy conversion process while also addressing carbon dioxide sustainability.
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This study explored the use of waste from the textile industry (silkworm byproducts) as a promising raw feedstock for the production of carbon-based adsorbents (biochar). The silk excreta biochar generated at 600 and 700 °C (referred to as SEB-600 and SEB-700, respectively) were evaluated in terms of their efficacy in adsorbing cationic (methylene blue) and anionic (Congo red) textile dyes. Although the functional groups on the surfaces of SEB-600 and SEB-700 were not significantly different, the specific surface area of SEB-700 was greater than that of SEB-600.

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Introduction: Human epidermal growth factor receptor 2 (HER2)-targeted therapies have shown effectiveness against HER2-positive breast cancer. This makes neoadjuvant chemotherapy (NAC) a valuable option for treating both early and advanced stages of the disease. The tumor's response to HER2-targeted NAC provides crucial prognostic information.

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To address the challenges associated with medical plastic waste and to characterize its heterogeneity, non-recyclability, and potential biohazard risks, this study explored a carbon dioxide (CO)-assisted pyrolysis process as a sustainable disposal method. Medical plastic waste typically includes polypropylene, polystyrene, and polyvinyl chloride. To experimentally evaluate the functional reactivity of CO, we employed three pyrolysis setups (one-stage, two-stage, and catalytic processes).

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Although Akkermansia muciniphila (Am) plays a beneficial role as a probiotic in the treatment of metabolic syndrome, the mechanisms remain elusive. We tested the hypothesis that Am extracellular vesicles (AmEVs) protect against hypertension through modulation of gene expression in the kidneys of spontaneously hypertensive rats (SHRs). Extracellular vesicles purified from anaerobically cultured Am (1.

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Empathy, crucial for social interaction, is impaired across various neuropsychiatric conditions. However, the genetic and neural underpinnings of empathy variability remain elusive. By combining forward genetic mapping with transcriptome analysis, we discover that aryl hydrocarbon receptor nuclear translocator 2 (ARNT2) is a key driver modulating observational fear, a basic form of affective empathy.

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Food waste (FW) comprises carbohydrates, proteins, lipids, and water, posing technical challenges for effective treatment and valorisation. This study addresses these challenges by using black soldier fly larvae (BSFL) as a bioconversion medium to transform FW into biodiesel (BD). BSFL predominantly consumed the carbohydrates and proteins in FW (81 wt%), while showing a lower preference for lipids (<50 wt% consumed).

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  • The study investigates the role of micrometastases in axillary lymph nodes after neoadjuvant systemic therapy (NST) in breast cancer patients, aiming to understand their impact on prognosis.
  • Among 978 analyzed patients, 9.1% had micrometastases, showing a higher prevalence of additional metastases compared to those without node involvement.
  • The findings suggest that while micrometastases do not affect recurrence-free survival, they are linked to worse outcomes, indicating that further axillary lymph node dissection may be necessary for affected patients.
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Healthcare delivery organizations (HDOs) in the US must contend with the potential for AI to worsen health inequities. But there is no standard set of procedures for HDOs to adopt to navigate these challenges. There is an urgent need for HDOs to present a unified approach to proactively address the potential for AI to worsen health inequities.

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Importance: Recovery of shoulder function following breast cancer surgery is crucial for physical functioning and quality of life. While early implementation of shoulder rehabilitation exercises may enhance recovery, the optimal timing and exercise program remain unclear.

Objective: To investigate whether an early exercise intervention, initiated 1 day postsurgery and continued for 1 month through subsequent visits, could improve shoulder range of motion (ROM) and strength in patients with breast cancer.

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Research on the applications of artificial intelligence (AI) tools in medicine has increased exponentially over the last few years but its implementation in clinical practice has not seen a commensurate increase with a lack of consensus on implementing and maintaining such tools. This systematic review aims to summarize frameworks focusing on procuring, implementing, monitoring, and evaluating AI tools in clinical practice. A comprehensive literature search, following PRSIMA guidelines was performed on MEDLINE, Wiley Cochrane, Scopus, and EBSCO databases, to identify and include articles recommending practices, frameworks or guidelines for AI procurement, integration, monitoring, and evaluation.

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: This study aimed to explore biomarker change after NAC (neoadjuvant chemotherapy) and to investigate biomarker expression as a prognostic factor in patients with residual disease (RD) after NAC. : We retrospectively evaluated 104 patients with invasive breast cancer, who underwent NAC and surgery at Pusan National University Hospital from 2015 to July 2022. The expression of the biomarker was assessed, and the overall survival (OS) and disease-free survival (DFS) were investigated.

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  • The use of AI and ML in healthcare is increasing rapidly, but guidelines and accountability measures to ensure their safe and fair use are lagging behind.
  • A workshop led to the creation of a framework called Health Equity Across the AI Lifecycle (HEAAL), aimed at evaluating the impact of AI solutions on health equity.
  • HEAAL includes criteria for assessing accountability, fairness, and transparency in AI adoption, with a total of 71 procedures to help healthcare organizations evaluate and implement AI responsibly, while mitigating risks to health equity.
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  • The text discusses a case of acute blockage of forearm supination in a 22-year-old male, likely due to a triangular fibrocartilage complex (TFCC) tear caused by a minor wrist injury during exercise two months prior.
  • MRI results confirmed the TFCC tear, which caused limitations in wrist movement and pain during supination, leading to the decision for arthroscopic surgery to remove the torn tissue blocking movement.
  • Post-surgery, the patient regained full forearm supination and experienced no pain, highlighting the effectiveness of addressing the TFCC tear for restoring wrist function.
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When integrating AI tools in healthcare settings, complex interactions between technologies and primary users are not always fully understood or visible. This deficient and ambiguous understanding hampers attempts by healthcare organizations to adopt AI/ML, and it also creates new challenges for researchers to identify opportunities for simplifying adoption and developing best practices for the use of AI-based solutions. Our study fills this gap by documenting the process of designing, building, and maintaining an AI solution called SepsisWatch at Duke University Health System.

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  • The study investigates the relationship between TFE3 and the PI3K/Akt pathway in renal cell carcinoma (RCC), focusing on how TFE3 expression is linked to cancer progression and patient prognosis.
  • TFE3 was manipulated in UOK146 cells using siRNA, shRNA, and pcDNA3.1 to assess its effect on phospho-Akt levels when treated with mTOR and PI3K inhibitors.
  • Results showed that TFE3 down-regulation increased phospho-Akt expression, while its up-regulation decreased it, suggesting that targeting the PI3K/Akt pathway could improve RCC treatment by impacting the tumor microenvironment.
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Akkermansia muciniphila (Am) shows a beneficial role as a probiotic in the treatment of metabolic syndrome. However, the mechanism remains to be elucidated. We tested the hypothesis that Am extracellular vesicles (AmEVs) have a protective effect against hypertension.

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This study explored the valorisation of silkworm by-product, a major by-product of the silk industry (sericulture), which amounts to 16 million tonnes annually. The focus was on transforming waste into energy resources through pyrolysis under CO conditions. In one-stage pyrolysis, the evolution of syngas under N was found to be comparable to that under CO.

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Purpose: Notable effectiveness of trastuzumab deruxtecan in patients with human epidermal growth factor receptor 2 (HER2)-low advanced breast cancer (BC) has focused pathologists' attention. We studied the incidence and clinicopathologic characteristics of HER2-low BC, and the effects of immunohistochemistry (IHC) associated factors on HER2 IHC results.

Materials And Methods: The Breast Pathology Study Group of the Korean Society of Pathologists conducted a nationwide study using real-world data on HER2 status generated between January 2022 and December 2022.

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  • Exosomal microRNAs (miRNAs) are linked to drug resistance in breast cancer, but their specific roles in clinical settings are not well understood, prompting this study to investigate their expression and target genes involved in drug resistance.
  • Researchers used microarray analysis to identify differentially expressed miRNAs (DEMs) in drug-resistant breast cancer, confirming the presence of miRNAs in tumor-derived exosomes (TDEs) from patient plasma samples.
  • A combination of five identified exosomal miRNAs was found to effectively predict responses to chemotherapy, with high sensitivity and specificity, highlighting their potential as predictive markers and therapeutic targets for improving breast cancer treatment outcomes.
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Objective: Achieving successful fusion during spine surgery is dependent on rigid pedicle screw fixation. To assess fixation strength, the insertional torque can be measured during intraoperative screw fixation. This study aimed to explore the technical feasibility of measuring the insertional torque of a pedicle screw, while investigating its relationship with bone density.

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