Pan-Pim Kinase Inhibitor AZD1208 Suppresses Tumor Growth and Synergistically Interacts with Akt Inhibition in Gastric Cancer Cells.

Purpose: Pim kinases are highly conserved serine/threonine kinases, and different expression patterns of each isoform (Pim-1, Pim-2, and Pim-3) have been observed in various types of human cancers, including gastric cancer. AZD1208 is a potent and selective inhibitor that affects all three isoforms of Pim. We investigated the effects of AZD1208 as a single agent and in combination with an Akt inhibitor in gastric cancer cells.

Cyclin E overexpression confers resistance to the CDK4/6 specific inhibitor palbociclib in gastric cancer cells.

Palbociclib is a specific inhibitor of CDK4/6 and has been shown to provide a survival benefit in hormone receptor-positive advanced breast cancer. TCGA database reported that about half of gastric cancers exhibit abnormalities in cell-cycle-related molecules, suggesting that gastric cancer is a good candidate for palbociclib treatment; however, the antitumor effects and predictive markers of palbociclib in gastric cancer remain incompletely described. Herein, the effect and predictive markers of palbociclib on gastric cancer cells were investigated.

Korean Cancer Patients' Awareness of Clinical Trials, Perceptions on the Benefit and Willingness to Participate.

Purpose: The purpose of this study was to assess current levels of awareness of clinical trials (CTs), perceptions regarding their benefits and willingness to participate to CTs among Korean cancer patients.

Materials And Methods: From December 2012 to August 2015, we distributed questionnaires to cancer patients receiving systemic anti-cancer therapy at Seoul National University Hospital, Seoul, Korea.

Results: A total of 397 out of 520 requested patients (76.

Antitumor Effect of KX-01 through Inhibiting Src Family Kinases and Mitosis.

Purpose: KX-01 is a novel dual inhibitor of Src and tubulin. Unlike previous Src inhibitors that failed to show clinical benefit during treatment of breast cancer, KX-01 can potentially overcome the therapeutic limitations of current Src inhibitors through inhibition of both Src and tubulin. The present study further evaluates the activity and mechanism of KX-01 and .

Paenibacillus harenae sp. nov., isolated from desert sand in China.

A Gram-positive, endospore-forming, rod-shaped bacterium, designated strain B519T, was isolated from a desert sand sample of Gansu Province, China. Strain B519T was strictly aerobic and cells were motile by means of peritrichous flagella. The strain grew optimally at 32-35 degrees C and pH 6.

Salinimicrobium terrae sp. nov., isolated from saline soil, and emended description of the genus Salinimicrobium.

A novel yellow-pigmented, Gram-negative, slightly halophilic, catalase-positive, oxidase-negative, obligately aerobic bacterium, designated strain YIM-C338(T), was isolated from saline soil from the Qaidam Basin in north-west China. Cells were non-sporulating, non-motile, short rods, predominantly occurring singly. Coccoid bodies and slightly curved rod-shaped cells of varying length developed in older cultures.

Gracilibacillus lacisalsi sp. nov., a halophilic Gram-positive bacterium from a salt lake in China.

Two Gram-positive, motile, rod-shaped, halophilic bacteria showing optimum growth at 5-7 % (w/v) NaCl were isolated from a salt lake, Xin-Jiang Province, China. The strains, designated BH312(T) and BH314, grew in the presence of 1-18 % (w/v) NaCl and at temperatures of 15-50 degrees C (optimum: 40 degrees C) and pH values of 5.5-10.

Reclassification of Salegentibacter catena Ying et al. 2007 as Salinimicrobium catena gen. nov., comb. nov. and description of Salinimicrobium xinjiangense sp. nov., a halophilic bacterium isolated from Xinjiang province in China.

A Gram-negative, non-motile and moderately halophilic rod-shaped bacterium, designated strain BH206(T), was isolated from a saline lake of Xinjiang province in China. The isolate showed catalase-positive and oxidase-negative reactions and did not reduce nitrate. Phylogenetic analysis based on 16S rRNA gene sequences showed that the isolate was most closely related to [Salegentibacter] catena HY1(T) with 95.

Albimonas donghaensis gen. nov., sp. nov., a non-photosynthetic member of the class Alphaproteobacteria isolated from seawater.

A moderately halophilic Gram-negative bacterium, strain DS2(T), was isolated from seawater from the East Sea in Korea. Strain DS2(T) grew at salinities of 0-14% (w/v) NaCl and at temperatures in the range 10-38 degrees C. The cells were non-motile short rods (1.

Bacillus kribbensis sp. nov., isolated from a soil sample in Jeju, Korea.

A Gram-positive, endospore-forming bacterium, designated strain BT080(T), was isolated from a soil sample in Jeju, Korea. Cells of the isolate were strictly aerobic rods that were motile by means of peritrichous flagella. The strain grew optimally at 30-33 degrees C and pH 5.

Halomonas kribbensis sp. nov., a novel moderately halophilic bacterium isolated from a solar saltern in Korea.

A moderately halophilic, Gram-negative bacterium, designated strain BH843(T), was isolated from a solar saltern in Korea and subjected to a taxonomic analysis. Strain BH843(T) grew at salinities of 1-14 % (w/v) NaCl and at temperatures of 10-40 degrees C. The cells were motile cocci or short rods with single flagella and contained C(16 : 0), C(19 : 0) cyclo omega8c and C(17 : 0) cyclo as the major fatty acids.

Leeia oryzae gen. nov., sp. nov., isolated from a rice field in Korea.

A strictly aerobic, non-spore-forming, Gram-negative bacterium, designated strain HW7(T), was isolated from a rice field in Korea. Cells of strain HW7(T) were short rod-shaped and motile with single polar flagella. The major cellular fatty acids of strain HW7(T) were C(16 : 0) and summed feature 3 (C(16 : 1)omega7c and/or iso-C(15 : 0) 2-OH).

Bacillus taeanensis sp. nov., a halophilic Gram-positive bacterium from a solar saltern in Korea.

A halophilic bacterium, strain BH030017(T), showing optimum growth at 2-5 % (w/v) NaCl was isolated from solar-saltern sediment from the Tae-An area of Korea and was characterized taxonomically. The cells of strain BH030017(T) were Gram-positive, motile, short rods containing cell-wall peptidoglycan based on meso-diaminopimelic acid. The major cellular fatty acids were anteiso-C(15 : 0) and iso-C(15 : 0).

Paenibacillus xinjiangensis sp. nov., isolated from Xinjiang province in China.

Strain B538T is a Gram-positive, motile, rod-shaped bacterium, which was isolated from Xinjiang province in China. This organism grew optimally at 30-35 degrees C and pH 8.0-8.

Paenibacillus gansuensis sp. nov., isolated from desert soil of Gansu Province in China.

A Gram-positive, endospore-forming, rod-shaped bacterium, designated strain B518(T), was isolated from a desert-soil sample from Gansu Province in China. The isolate was strictly aerobic and was motile by means of several flagella. The strain grew optimally at 35-40 degrees C and at pH 7.

Bacillus seohaeanensis sp. nov., a halotolerant bacterium that contains L-lysine in its cell wall.

A halotolerant, round-endospore-forming, aerobic, Gram-positive bacterium, designated BH724(T), was isolated from a solar saltern at Taean in Korea. Cells of this strain were rod-shaped and found to be non-motile. Strain BH724(T) grew at salinities of 0-10 % (w/v) NaCl with an optimum of 3 % (w/v) NaCl and at temperatures of 15-50 degrees C with an optimum of 40 degrees C.

Marinimicrobium koreense gen. nov., sp. nov. and Marinimicrobium agarilyticum sp. nov., novel moderately halotolerant bacteria isolated from tidal flat sediment in Korea.

Two moderately halotolerant Gram-negative bacteria were isolated from tidal flat sediment of the South Sea in Korea (the Korea Strait). The strains, designated M9T and M18T, were strictly aerobic, rod-shaped and non-spore-forming and motile with a flagellum and their major fatty acids were C(16:0) and C(19:0) cyclo omega8c. Strains M9T and M18T could grow in the presence of up to 13-15% (w/v) NaCl, but their optimum salt concentrations were relatively low (0-3%, w/v).

Bacillus salarius sp. nov., a halophilic, spore-forming bacterium isolated from a salt lake in China.

A moderately halophilic bacterium, strain BH169T, capable of growing at salinities of 3-20% (w/v) NaCl was isolated from a saline lake in China. Strain BH169T was strictly aerobic, short-rod-shaped and non-motile (non-flagellated). Its major cellular fatty acids were anteiso-C15:0, anteiso-C17:0, iso-C15:0 and iso-C16:0.

Virgibacillus koreensis sp. nov., a novel bacterium from a salt field, and transfer of Virgibacillus picturae to the genus Oceanobacillus as Oceanobacillus picturae comb. nov. with emended descriptions.

A novel Virgibacillus strain, BH30097T, was isolated from a salt field near Taean-Gun on the Yellow Sea in Korea. Cells were Gram-positive rods and bore ellipsoidal endospores in terminal positions. The optimum pH and temperature for growth of this organism were pH 7 and 25 degrees C, respectively.

Bacillus koreensis sp. nov., a spore-forming bacterium, isolated from the rhizosphere of willow roots in Korea.

An endospore-forming, rod-shaped bacterium was isolated from the rhizosphere of willow roots in Korea. The bacterium, designated strain BR030T, was a strictly aerobic, motile rod. The cell wall contained type A1gamma peptidoglycan with meso-diaminopimelic acid as the diagnostic diamino acid.

Halomonas taeanensis sp. nov., a novel moderately halophilic bacterium isolated from a solar saltern in Korea.

A moderately halophilic, Gram-negative bacterium, strain BH539(T), which was isolated from a solar saltern at Taean in Korea, was considered to be a member of the genus Halomonas. Strain BH539(T) grew at salinities of 1-25% (w/v) and at temperatures of 10-45 degrees C. Cells were short rods that were motile by means of several flagella.

Reclassification of Bacillus haloalkaliphilus Fritze 1996 as Alkalibacillus haloalkaliphilus gen. nov., comb. nov. and the description of Alkalibacillus salilacus sp. nov., a novel halophilic bacterium isolated from a salt lake in China.

A spore-forming, halophilic bacterium, designated strain BH163(T), was isolated from a salt lake in China. Cells were motile, strictly aerobic rods that contained type A1gamma peptidoglycan with meso-diaminopimelic acid as the diagnostic diamino acid. The isolate showed Gram- and catalase-positive reactions and formed a terminal endospore with a swollen sporangium.

Lentibacillus lacisalsi sp. nov., a moderately halophilic bacterium isolated from a saline lake in China.

An aerobic, spore-forming, moderately halophilic bacterium, strain BH260(T), was isolated from a salt lake in China. Cells of this strain were found to be motile rods with flagella. The organism grew optimally at 30-32 degrees C and pH 8.

Lentibacillus salarius sp. nov., isolated from saline sediment in China, and emended description of the genus Lentibacillus.

A Gram-positive, spore-forming and moderately halophilic bacterium, strain BH139(T), was isolated from saline sediment of Xinjiang Province, China. Cells of strain BH139(T) were motile, flagellated rods. The organism grew optimally at 30-35 degrees C in the presence 12-14 % (w/v) NaCl.

Pontibacillus marinus sp. nov., a moderately halophilic bacterium from a solar saltern, and emended description of the genus Pontibacillus.

A moderately halophilic, Gram-positive, rod-shaped bacterium (BH030004(T)) was isolated from a solar saltern in Korea. Phylogenetic analysis based on 16S rRNA gene sequences showed that strain BH030004(T) belonged to the genus Pontibacillus. Chemotaxonomic data (DNA G + C content, 42 mol%; major isoprenoid quinone, MK-7; cell-wall type, A1gamma-type meso-diaminopimelic acid; major fatty acids, iso-C(15 : 0) and anteiso-C(15 : 0)) also supported the affiliation of the isolate to the genus Pontibacillus.