Publications by authors named "Jee Eun Park"
Article Synopsis
- Advances in the development of amyloid β-specific human Tregs (Aβ-hTreg) show promise for treating Alzheimer's disease (AD), despite challenges with Treg selection and expansion.
- A successful ex vivo expansion method was established, leading to a phase 1 clinical trial with six Alzheimer's patients that evaluated the safety and initial efficacy of Aβ-hTreg.
- Results indicated improved cognitive function and safety of the treatment in mice, while no significant toxicity was observed in patients, suggesting a potential pathway for future AD clinical trials.
Objective: This study investigated to what extent a range of depressive symptoms was differentially present depending on age group in Korean population.
Methods: Data was pooled from five nationally representative surveys in which 29,418 respondents aged at least 18 years were interviewed face-to-face using the Korean version of the Composite International Diagnostic Interview. A total of 691 (2.
Article Synopsis
- The Seoul Intensive Case Management program (S-ICM) was implemented in 2017 to improve outcomes for patients with serious mental illnesses by reducing hospital stay.
- A study analyzed data from 759 participants to compare average lengths of hospital admission before, during, and after the S-ICM implementation, finding significant reductions in stay duration during the program.
- Results showed that S-ICM effectively shortens psychiatric hospitalizations, indicating its potential benefits for patients with severe mental health issues, particularly in the short term.
Background: Cognitive impairment is a core symptom that profoundly impacts the lives of people with multiple sclerosis (PwMS). Since the existing disease modifying therapies can only stabilize, but not actively treat, cognition in PwMS, there is an unmet need to expand approaches to treat these cognitive symptoms. Transcranial alternating current stimulation (tACS) permits frequency-specific entrainment of neural oscillations intrinsic to cognitive activity.
View Article and Find Full Text PDFObjective: The Patient Health Questionnaire-9 (PHQ-9) and PHQ-2 have not been validated in the general Korean population. This study aimed to validate and identify the optimal cutoff scores of the PHQ-9 and PHQ-2 in screening for major depression in the general Korean population.
Methods: We used data from 6,022 participants of the Korean Epidemiological Catchment Area Study for Psychiatric Disorders in 2011.
Article Synopsis
- The study examines mental disorders in Korea, revealing a lifetime prevalence of 27.8% among the general population.
- The survey highlighted specific 12-month prevalence rates for various disorders: alcohol use (2.6%), nicotine use (2.7%), depression (1.7%), and anxiety (3.1%).
- It also identified risk factors for these disorders and noted that treatment rates for mental health issues were notably low, emphasizing the need for further research and improved access to mental health services.
Background: Biogenetic causal explanations of mental disorders are commonly used for public education and campaigns. However, the influence of biogenetic explanations on the ideas about and attitudes toward mental illness is unclear. We examined the influence of biogenetic explanations on attitudes toward mental disorders using a meta-analytic method accompanied by subgroup analyses.
View Article and Find Full Text PDFPurpose: This qualitative study examined the inner response of medical students who participated in a transgender healthcare education program. The factors that effected the inner response were investigated in order to suggest strategies for improving the effectiveness of the transgender healthcare education program.
Methods: The transgender healthcare education program consisted of 2 hours of lectures and 2 hours of clinical role-play over 3 weeks.
Background: Postoperative delirium is a challenging complication due to its adverse outcome such as long hospital stay. The aims of this study were: 1) to identify preoperative risk factors of postoperative delirium following knee arthroplasty, and 2) to develop a machine-learning prediction model.
Method: A total of 3,980 patients from two hospitals were included in this study.
Background: The psychiatric treatment gap is substantial in Korea, implying barriers in seeking help.
Objectives: This study aims to explore barriers of seeing psychiatrists, expressed on the internet by age groups.
Methods: A corpus of data was garnered extensively from internet communities, blogs and social network services from 1 January 2016 to 31 July 2019.
Background: Air pollution control is necessary to decrease the burden on older adults with cognitive impairment, especially in low- and middle-income countries (LMICs).
Objective: This study retrospectively examined the effect of cumulative exposure to air pollution, including NO2, SO2, CO, fine particulate matter (PM)10, PM2.5, and O3, on cognitive function in older individuals.
Background: The number of digital game users is increasing, and so is attention to digital gaming's effects on mental health. We aimed to reveal if risky (game addiction) and usual game use (non-risky) are associated with mental health in early adulthood.
Methods: Using data from the nationwide cross-sectional Korean Epidemic Catchment Area study for psychiatric disorders, 415 participants aged 18-30 years were divided into "non-game," "usual game," and "risky game" user groups based on the previous month's game use and cut-off value of game overuse screening questionnaire.
Article Synopsis
- The study explored how aging and Alzheimer’s disease (AD) differently impact sleep patterns and daily activity rhythms in a diverse group of participants aged 20 to 90.
- While older adults without AD maintained good sleep quality and a regular daily rhythm, preclinical AD showed earlier circadian phases but clinical AD resulted in later rhythms and longer sleep durations.
- Overall, the research suggests that normal aging promotes a consistent activity rhythm without affecting sleep length, while AD progression alters these patterns, emphasizing the distinct effects of age and disease on sleep.
Study Objectives: Idiopathic rapid eye movement sleep behavior disorder (iRBD), characterized by rapid eye movement sleep without atonia (RSWA) and dream-enactment behavior, has been suggested to be a predictor of α-synucleinopathies. Autonomic instability, represented by heart rate variability, is a common characteristic of both iRBD and α-synucleinopathies. Previous studies reported that RSWA was associated with autonomic dysfunction and was a possible predictor of phenoconversion.
View Article and Find Full Text PDFBackground: The degree of alpha attenuation from eyes-closed (EC) to eyes-open (EO) has been suggested as a neural marker of cognitive health, and its disruption has been reported in patients with clinically defined Alzheimer's disease (AD) dementia.
Objective: We tested if EC-to-EO alpha reactivity was related to cerebral amyloid-β (Aβ) deposition during the early stage of AD.
Methods: Non-demented participants aged ≥55 years who visited the memory clinic between March 2018 and June 2019 (N = 143; 67.
Objective: We aimed to compare cerebral beta-amyloid protein (Aβ) positivity rate and amyloid accumulation pattern on amyloid positron emission tomography (PET) between mild cognitive impairment (MCI) subtypes, i.e. amnestic mild cognitive impairment (aMCI) and non-amnestic mild cognitive impairment (naMCI).
View Article and Find Full Text PDFAims: The aim of the current study was to develop and validate a short-form of the internet overuse screening questionnaire (IOS-Qs).
Methods: A total of 571 adults were recruited from a representative, stratified, and multistage cluster sample. Among participants, 188 and 383 were used in the development and validation of the IOS-Qs, respectively.
Purpose: To investigate age-related differences in the relationships among at-risk alcohol consumption, alcohol use disorder (AUD), and psychological distress with a special focus on older adults.
Methods: We used a nationwide cross-sectional study of a representative sample of community-dwelling adults from the Korean Epidemiologic Catchment Area study for psychiatric disorders conducted by door-to-door interviews. The Korean version of the Composite International Diagnostic Interview was applied.