Publications by authors named "Jeb English"
Radiation-induced lung injury (RILI) initiates radiation pneumonitis and progresses to fibrosis as the main side effect experienced by patients with lung cancer treated with radiotherapy. There is no effective drug for RILI. Sustained vascular activation is a major contributor to the establishment of chronic disease.
View Article and Find Full Text PDFWhole Abdominal Pencil Beam Scanned Proton FLASH Increases Acute Lethality.
Int J Radiat Oncol Biol Phys
September 2024
Article Synopsis
- - The study investigates the effects of ultrahigh dose-rate FLASH proton therapy on gastrointestinal injury, highlighting that while FLASH therapy aims to reduce normal tissue toxicity, it showed significantly reduced survival rates in mice compared to conventional therapy.
- - Whole abdominal irradiation was conducted on mice, using both FLASH and conventional proton therapy, and survival rates were assessed, along with intestinal histology analysis through a new AI-based technique.
- - Results indicated that despite enhanced dose rates with FLASH therapy, there was no significant improvement in gut cell regeneration or histology at 4 days post-irradiation, raising questions about FLASH's efficacy for gastrointestinal sparing.
Unlabelled: Radionuclide irradiators (137Cs and 60Co) are commonly used in preclinical studies ranging from cancer therapy to stem cell biology. Amidst concerns of radiological terrorism, there are institutional initiatives to replace radionuclide sources with lower energy X-ray sources. As researchers transition, questions remain regarding whether the biological effects of γ-rays may be recapitulated with orthovoltage X-rays because different energies may induce divergent biological effects.
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