Treatment Outcomes in Children With Catecholaminergic Polymorphic Ventricular Tachycardia: A Single Institutional Experience.

Background And Objectives: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a life-threatening inherited arrhythmogenic disorder. Recently, , the major CPVT-causative gene, was associated with neuropsychiatric manifestations. We aimed to analyze the clinical presentations, neuropsychiatric manifestations, and treatment outcomes of children with CPVT.

Neurotoxic effects of citronellol induced by the conversion of kynurenine to 3-hydroxykynurenine.

Citronellol is widely utilized in consumer products, including cosmetics, fragrances, and household items. However, despite being considered a relatively safe chemical, the health effects and toxicity mechanisms associated with exposure to high concentrations of citronellol, based on product content, remain inadequately understood. Here, we aimed to analyze the neurological effects of citronellol in zebrafish larvae using behavioral and histological analyses and elucidate the mechanisms underlying its neurotoxicity in vivo.

Characterizing autogenous and reactive obsessions using theta and beta oscillations under inhibitory demands.

Obsessive-Compulsive Disorder (OCD) is a heterogenous mental health condition that causes significant impairment and is often associated with poor treatment outcomes. The aim of the current study was to examine the association between electroencephalographic (EEG) oscillatory power during inhibitory task performance and obsessive-compulsive symptoms (OCS). OCS was assessed using the well-established the Autogenous-Reactive Obsession (AO-RO) model as the main framework to address its heterogeneous clinical manifestations.

High sleep reactivity in shift workers is associated with increased sleep disturbance, mood problems, and reduced quality of life.

Introduction: Shift work disrupts circadian rhythms, causing sleep and mood problems. Sleep reactivity-the sensitivity of sleep to stress-may affect how shift workers cope with these disruptions. This study investigated the relationship between sleep reactivity and shift work, exploring associations between sleep reactivity and sleep disturbance, mood symptoms, and quality of life in shift workers.

Relationship between dietary diversity, eating behavior, and cognitive performance in economically disadvantaged school children.

Objective: The effect of dietary diversity and eating behavior on attention, and concentration among children lacking in resources is unclear. We aim to investigate the association between dietary diversity, eating behavior, and cognitive abilities among economically disadvantaged children at high risk of cognitive impairment.

Methods: This study enrolled 676 children aged 10-12 years from 16 free academic tutoring centers across Taiwan.

Identifying potential medical aid beneficiaries using machine learning: A Korean Nationwide cohort study.

Objective: To identify potential medical aid beneficiaries using demographic and medical history of individuals and analyzing important features qualitatively.

Methods: This retrospective, national cohort, case-control study included data from the National Health Insurance Service (NHIS) in Korea between January 1, 2002 and December 31, 2019. Potential medical aid beneficiaries were classified using several machine learning models (linear models and tree-based models).

Vibration therapy for patients with hard-to-heal wounds: A systematic review and meta-analysis of experimental studies.

Introduction: Hard-to-heal wounds lead to functional loss, decreased quality of life, and prolonged hospitalization due to delayed healing. The healthcare costs of managing such wounds are substantial. Vibration therapy has been proposed as an alternative treatment for hard-to-heal wounds but no comprehensive reviews have quantitatively analyzed its efficacy.

Escalating Lipid Therapy After Achieving LDL-C <70 mg/dL With Moderate-Intensity Statins in High-Risk Patients.

Background And Objectives: Guidelines recommend target levels of low-density lipoprotein cholesterol (LDL-C) and intensive lipid-lowering therapy (LLT) in high-risk patients. However, the value of escalating LLT when the LDL-C targets are achieved with moderate-intensity statins is unknown. We aimed to evaluate the benefits of LLT escalation in this population.

Feasibility of Distal Radial Access in High Bleeding Risk Patients Who Underwent Percutaneous Coronary Intervention.

Backgrounds And Objectives: The distal radial access (DRA), a potential alternative to the trans-radial approach (TRA), may offer advantages in terms of access site complications due to its smaller vessel diameter, especially for high bleeding risk (HBR) patients. This study aims to investigate the feasibility of DRA in HBR patients.

Methods: Based on data from the KODRA registry, a prospective, multicenter cohort, this study analyzed 1,586 patients who underwent successful percutaneous coronary intervention (PCI) via DRA.

Cardiovascular Etiologies and Risk Factors of Survival Outcomes After Resuscitation for Out-of-Hospital Cardiac Arrest: Data From the KoCARC Registry.

Background And Objectives: The outcomes and characteristics of out-of-hospital cardiac arrest (OHCA) vary across geographic regions. The etiologies and prognoses of OHCA in Asian populations remain less established. This study aimed to investigate the etiologies and clinical characteristics of patients successfully resuscitated after OHCA and to identify predictors of survival outcomes.

Safety and Feasibility of Robot-Assisted Percutaneous Coronary Intervention Using the AVIAR 2.0 System: A Prospective, Multi-Center, Single-Arm, Open, Investigator-Initiated, Post-Approval Clinical Trial.

Background And Objectives: Traditional manual percutaneous coronary intervention (PCI) exposes operators to significant radiation and physical stress. The recently developed Advanced Vascular Intervention Assist Robot (AVIAR) 2.0 system in South Korea aimed to overcome these issues by evaluating its safety and feasibility in a clinical setting.

Intermarrying MOF Glass and Lead Halide Perovskites for Artificial Photosynthesis.

The development of efficient artificial photosynthesis systems is crucial for sustainable chemical production, as they mimic natural processes to convert solar energy into chemical products, thereby addressing both energy and environmental challenges. The main bottlenecks in current research include fabricating highly selective, stable, and scalable catalysts, as well as effectively harnessing the full spectrum of light, particularly the low-energy, long-wavelength portion. Herein, we report a novel composite photocatalyst system based on lead halide perovskites embedded in functionalized MOF glass.

Missing History: Anarcha, Betsey, and Lucy's Legacy in Gynecologic Textbooks.

The legacy of J. Marion Sims as the "father of gynecology" has become widely controversial among medical professionals and lay public because of ethical concerns surrounding the development of his surgical techniques and his exploitation of enslaved women for his experiments. Notably, in April 2018, the City of New York relocated a commemorative statue of Sims from Central Park following an art commission's investigation of his controversial practices.

Evaluating the impact of modeling choices on the performance of integrated genetic and clinical models.

Purpose: The value of genetic information for improving the performance of clinical risk prediction models has yielded variable conclusions. Many methodological decisions have the potential to contribute to differential results. We performed multiple modeling experiments integrating clinical and demographic data from electronic health records (EHR) with genetic data to understand which decisions may affect performance.

Long-term use of proton pump inhibitors was associated with rapid progression to end stage kidney disease in a Korean nationwide study.

Proton pump inhibitors (PPIs) are among the most widely used drugs worldwide. However, their influence on the progression of end-stage kidney disease (ESKD) in established chronic kidney disease (CKD) cases is unclear. Using the Korean Health Insurance Review and Assessment database encoded by the Observational Medical Outcomes Partnership-Common Data Model (OMOP-CDM), patients with stage 3 or 4 CKD initiating PPIs or histamine-2 receptor antagonists (H2RAs) for over 90 days were enrolled from 2012 through 2021.

Prognostic value of pseudotime from texture parameters of FDG PET/CT in locally advanced rectal cancer with neoadjuvant concurrent chemoradiotherapy.

Texture analysis generates image parameters from F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT). Although some parameters correlate with tumor biology and clinical attributes, their types and implications can be complex. To overcome this limitation, pseudotime analysis was applied to texture parameters to estimate changes in individual sample characteristics, and the prognostic significance of the estimated pseudotime of primary tumors was evaluated.

Exploring the reaction dynamics of alanine racemase using serial femtosecond crystallography.

Alanine racemase (Alr) catalyzes the pyridoxal 5'-phosphate (PLP)-dependent racemization between L- and D-alanine in bacteria. Owing to the potential interest in targeting Alr for antibacterial drug development, several studies have determined the structures of Alr from different species, proposing models for the reaction mechanism. Insights into its reaction dynamics may be conducive to a better understanding of the Alr reaction mechanism.

Exploring potential multiple molecular biomarkers that predict treatment response in patients with lupus nephritis.

Limited knowledge exists regarding biomarkers that predict treatment response in Lupus nephritis (LN). We aimed to identify potential molecular biomarkers to predict treatment response in patients with LN. We enrolled 66 patients with active LN who underwent renal biopsy upon enrollment.

Identification and validation of KIF20A for predicting prognosis and treatment outcomes in patients with breast cancer.

Breast cancer is a leading cause of cancer-related deaths among women globally. It is imperative to explore novel biomarkers to predict breast cancer treatment response as well as progression. Here, we collected six breast cancer samples and paired normal tissues for high-throughput sequencing.

Synthetic polarization-sensitive optical coherence tomography using contrastive unpaired translation.

Polarization-sensitive optical coherence tomography (PS-OCT) measures the polarization state of backscattered light from tissues and provides valuable insights into the birefringence properties of biological tissues. Contrastive unpaired translation (CUT) was used in this study to generate a synthetic PS-OCT image from a single OCT image. The challenges related to extensive data requirements relying on labeled datasets using only pixel-wise correlations that make it difficult to efficiently regenerate the periodic patterns observed in PS-OCT images were addressed.

Integrated analysis of rumen metabolomics and metataxonomics to understand changes in metabolic and microbial community in Korean native goats under heat stress.

Heat stress (HS) is an impactful condition in ruminants that negatively affects their physiological and rumen microbial composition. However, a fundamental understanding of metabolomic and metataxonomic mechanisms in goats under HS conditions is lacking. Here, we analyzed the rumen metabolomics, metataxonomics, and serum metabolomics of goats (n = 10, body weight: 41.