Publications by authors named "Jeanne Thomassin"
Fully Automated Artificial Intelligence Solution for Human Epidermal Growth Factor Receptor 2 Immunohistochemistry Scoring in Breast Cancer: A Multireader Study.
JCO Precis Oncol
October 2024
Article Synopsis
- The study aimed to assess the accuracy of a fully automated AI solution for interpreting HER2 immunohistochemistry (IHC) in breast cancer, acknowledging the need for more reliable HER2 scoring due to the effectiveness of HER2-targeted therapies.
- In a two-arm study involving 120 HER2 IHC whole-slide images and four surgical pathologists, the AI solution showed improved interobserver agreement and scoring accuracy compared to manual readings, particularly for distinguishing between HER2 0 and 1+ cases.
- The results indicate that the AI tool can enhance the consistency and reproducibility of HER2 scoring, supporting pathologists in following ASCO/CAP guidelines more effectively.
Endoscopic Ultrasound-Guided Radiofrequency Ablation as an Future Alternative to Pancreatectomy for Pancreatic Metastases from Renal Cell Carcinoma: A Prospective Study.
Cancers (Basel)
October 2021
Background: Pancreatic metastases (PM) from renal cell carcinoma (RCC) are rare, are associated with favorable outcomes and are usually handled by surgery or VEGFR inhibitors, which both have side effects. Endoscopic Ultrasound (EUS)-guided radiofrequency ablation (RFA) is an innovative approach to treat focally deep metastases and could be a relevant technique to control PM from RCC.
Methods: This monocentric, prospective study aimed to evaluate the safety and efficacy of EUS-RFA to treat PM.
We report a case of mucinous adenocarcinoma developed on sigmoid colpoplasty, performed for a congenital agenesis vaginal. The cancer development of neovagina remains exceptional. Its management consists, in the majority of cases, in surgery for a complete excision.
View Article and Find Full Text PDFRenal cell carcinoma is the third most prevalent urological cancer worldwide and about 30% of patients present with metastatic disease at the time of diagnosis. Systemic treatments for metastatic renal cell carcinoma have improved recently. Vascular endothelial growth factor targeting therapies were the previous standard of care.
View Article and Find Full Text PDFUp to 40% of patients with renal cell carcinoma (RCC) with initially localized disease eventually develop metastasis following nephrectomy. The current standard of care for metastatic RCC (mRCC) is targeted therapy. However, complete response remains rare.
View Article and Find Full Text PDFBackground: Glandular metastases (GMs) (pancreas, breast, parotid, thyroid, or contralateral adrenal) are rare in metastatic clear cell renal cell carcinoma (mccRCC). In a multicenter study we have assessed outcome from mccRCC with or without GMs.
Patients And Methods: Patients with mccRCC and GM or non-GM (NGM) at first presentation of mccRCC, treated at 9 European centers (5 French, 3 UK, and 1 Belgian centers) between January 2004 and October 2013, were retrospectively analyzed.
Background: The role of completion surgery after concurrent radiochemotherapy (CCRC) for advanced cervical cancer remains controversial. Individual predictive factors of CCRC response and survival are mandatory for treatment adaptation and to determine a population who would take interest in completion surgery after CCRC. The aim of this study was to evaluate the ability of biomarkers to predict the response to CCRC.
View Article and Find Full Text PDFMetastasis is a major clinical issue and results in poor prognosis for most cancers. The Junctional Adhesion Molecule-C (JAM-C) expressed by B16 melanoma and endothelial cells has been involved in metastasis of tumor cells through homophilic JAM-C/JAM-C trans-interactions. Here, we show that JAM-B expressed by endothelial cells contributes to murine B16 melanoma cells metastasis through its interaction with JAM-C on tumor cells.
View Article and Find Full Text PDFPurpose: To retrospectively evaluate the diagnostic performance of dynamic contrast material-enhanced magnetic resonance (MR) imaging for the characterization of ovarian epithelial tumors, by using histologic findings as the reference standard, and to correlate dynamic contrast-enhanced MR imaging findings with angiogenesis biomarkers.
Materials And Methods: Ethics committee approval was obtained, with waiver of informed consent. Patients consented to having their data used for future retrospective research.