Publications by authors named "Jeanne Perroteau"
Article Synopsis
- * Found that the LAT adaptor forms larger molecular structures, showing that TCR signaling networks are largely similar in both human CD4+ and CD8+ T cells, and even between humans and mice, including protein-protein interaction ratios.
- * Suggested that drugs targeting the proximal TCR signaling network would work similarly in human and mouse T cells, but differences may exist in the distal signaling pathways; using an LCK inhibitor illustrated how this fast-track AP-MS method can aid in understanding drug mechanisms for human T
Invariant Natural Killer T (iNKT) cells are particular T lymphocytes at the frontier between innate and adaptative immunities. They participate in the elimination of pathogens or tumor cells, but also in the development of allergic reactions and autoimmune diseases. From their first descriptions, the phenomenon of self-reactivity has been described.
View Article and Find Full Text PDFPurpose: Cellular immunotherapies are currently being explored to eliminate highly invasive and chemoradioresistant glioblastoma (GBM) cells involved in rapid relapse. We recently showed that concomitant stereotactic injections of nonalloreactive allogeneic Vγ9Vδ2 T lymphocytes eradicate zoledronate-primed human GBM cells. In the present study, we investigated the spontaneous reactivity of allogeneic human Vγ9Vδ2 T lymphocytes toward primary human GBM cells, and , in the absence of any prior sensitization.
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