Publications by authors named "Jeanne Lena"
Purpose: Molecular profiling is increasingly implemented to guide treatment of advanced pancreatic ductal adenocarcinoma (PDAC), especially when for clinical trials enrollment. This study aimed to describe actionable alterations detected in KRAS mutated (KRASm) versus KRAS wild-type (KRASwt) PDAC, the latter group being considered enriched in molecular alterations.
Methods: This prospective monocentric study included patients with locally advanced or metastatic PDAC who underwent next-generation sequencing (NGS) on liquid biopsy and/or tissue samples between 2015 and 2023, as part of the BIP academic study (NCT02534649).
Background: The impact of local management of pulmonary metastases on the disease course of patients with metastatic colorectal cancer is poorly assessed.
Methods: REPULCO database was a retrospective cohort on 18 years that included all patients treated for lung metastases from colorectal cancer who received local and/or systemic treatments.
Aims: Primary objective was overall survival, secondary were progression-free survival and survival without chemotherapy.
Article Synopsis
- Researchers studied if mutation testing can help improve the diagnosis of pancreatic cancer using a special needle method called EUS-FNB.
- They found that almost a third of the samples didn't give a clear diagnosis, but mutation testing could help identify cancer in nearly half of those cases.
- The results suggest that using mutation tests more often could speed up treatment and help doctors choose the best type of therapy for patients.