Publications by authors named "Jeanmarie Mishler"
Article Synopsis
- - Multiple myeloma is the second most common blood cancer, and even with improved treatments, many patients experience relapses that lead to a poor outlook.
- - A study involving 511 patients with relapsed, refractory multiple myeloma found that genetic changes in the NF-κB and RAS/MAPK pathways are more frequent than previously thought, affecting 45-65% of patients.
- - The research also identified various genetic alterations linked to resistance against targeted therapies, found in 22% of patients, and highlighted the presence of activating mutations in IL6ST, offering insights for future research and clinical strategies.
Replication stress causes breaks at chromosomal locations called common fragile sites. Deletions causing loss of heterozygosity (LOH) in human tumors are strongly correlated with common fragile sites, but the role of gene conversion in LOH at fragile sites in tumors is less well studied. Here, we investigated gene conversion stimulated by instability at fragile site FS2 in the yeast Saccharomyces cerevisiae In our screening system, mitotic LOH events near FS2 are identified by production of red/white sectored colonies.
View Article and Find Full Text PDF