Publications by authors named "Jeanine Ohl"

Objectives: The new bioethics law of August 2, 2021 allows French women to self-preserve.

Methods: National observational survey over 2 years based on an online questionnaire conducted under the aegis of GEDO (Groupe d'études pour le don d'ovocytes).

Results: The average age of the 282 women who answered the questionnaire, 34.

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Article Synopsis
  • The French Bioethics Law now allows lesbian couples and single women to access medically assisted reproduction, including the use of cryopreserved gametes, raising questions about new applications of these gametes among various couples, particularly those including transgender individuals.
  • The study analyzes scenarios where a transgender woman's sperm is used within couples, rather than relying on gamete donation, highlighting existing practices and challenges faced by healthcare professionals.
  • There are inconsistencies and legal gaps related to using a trans woman's sperm under the new EUGIC framework, resulting in complexities for medical practitioners and raising issues around the rights and interests of the unborn child.
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Purpose: This study aimed to describe the phenotypic and molecular characteristics of ARCN1-related syndrome.

Methods: Patients with ARCN1 variants were identified, and clinician researchers were connected using GeneMatcher and physician referrals. Clinical histories were collected from each patient.

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Article Synopsis
  • The study evaluated the effectiveness of customized embryo transfers (cET) based on a transcriptomic approach (Win-Test) for patients with repeated implantation failure (RIF), involving 217 participants.
  • The Win-Test assessed the expression of 11 endometrial genes to determine the optimal receptivity window for embryo transfer, revealing that a significant majority (80%) of patients had receptivity timing that differed from the classical protocol.
  • Results showed that pregnancy and live birth rates were significantly higher in the cET group (22.7% and 31.8%) compared to the control group (7.2% and 8.3%), suggesting cET based on Win-Test findings could enhance outcomes for patients with RIF.
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Introduction: The objective of this study was to assess the impact on the clinical pregnancy rate of luteal phase progesterone treatment in patients being prepared for natural cycle frozen embryo transfer (FET) with induced ovulation.

Material And Methods: This retrospective cohort study collect all the FET protocols over a 6-month period at Strasbourg University Hospital fertility unit between December 2016 and May 2017. In total 293 consecutive patients with regular menstrual cycles were prepared for natural cycle FET during this period.

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Objective: This study aimed to assess the application of the French guidelines for pregnancies in Turner syndrome (TS) and their impact on perinatal prognosis.

Study Design: We performed a French multi-center retrospective study (14 centers), including TS pregnant patients (spontaneously or by Assisted Reproductive Technology (ART)) between January 2006 and July 2017. Only clinical pregnancies were analyzed.

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Objective: To determine whether egg donation (ED) pregnancies are at higher risk of pregnancy-induced hypertension (PIH) than those achieved by autologous assisted reproductive technology (ART; controls).

Design: Anonymous comparative observational matched cohort study.

Setting: Assisted reproductive technology centers.

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Context: Recombinant human GH treatment and oocyte donation (OD) have improved the quality of life in women with Turner syndrome (TS). However, life expectancy is reduced, mainly due to cardiovascular complications. Pregnancy may itself increase that risk and be associated with hazardous materno-fetal outcome.

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Article Synopsis
  • * A joint committee was formed, including various medical societies and the Biomedicine Agency, to develop specific questions and select experts to address the issues pertaining to Turner syndrome patients.
  • * The committee aimed to gather recommendations on pre-pregnancy check-ups, pregnancy guidelines, and comprehensive care for Turner syndrome patients before, during, and after pregnancy.
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Objective: To examine the safety and effectiveness of assisted reproduction using sperm washing for HIV-1-serodiscordant couples wishing to procreate where the male partner is infected.

Design And Methods: A retrospective multicentre study at eight centres adhering on the European network CREAThE and involving 1036 serodiscordant couples wishing to procreate. Sperm washing was used to obtain motile spermatozoa for 3390 assisted reproduction cycles (2840 intrauterine inseminations, 107 in-vitro fertilizations, 394 intra-cytoplasmic sperm injections and 49 frozen embryo transfers).

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Background: Assisted reproduction technologies can treat infertility for human immunodeficiency virus (HIV) seropositive women. We assessed the efficacy of these techniques in the results and difficulties encountered while conducting our assisted reproduction programme for 49 couples in which at least the woman had HIV infection that was currently under control.

Methods: Treatments included intrauterine insemination (IUI), IVF and ICSI, with ovarian stimulation.

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Background: Assisted reproduction techniques can minimize the risk of infection and treat possible sterility associated with serodiscordant couples.

Methods: We assessed the efficacy of these techniques in 57 couples in which at least one partner had human immunodeficiency virus (HIV-1) infection that was currently under control (47 men and 10 women). The semen of seropositive men was prepared and tested for viruses.

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Background: Nitric oxide (NO) is involved in local control of the uterine cycle and in preparation of the uterus for pregnancy. NO donors, acting as vasodilating agents, may therefore have possible therapeutic uses, for example they may be of benefit to patients with a history of implantation failure. In a prospective, comparative, randomized, placebo-controlled study, we assessed the efficacy of nitroglycerin (NTG) administered to 138 IVF patients with a history of implantation failure.

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