Publications by authors named "Jeanie K Meckes"
The role of stress in altering fear memory is not well understood. Since individual variations in stress reactivity exist, and stress alters fear memory, exposing individuals with differing stress-reactivity to repeated stress would affect their fear memory to various degrees. We explored this question using the average stress-reactive Fisher 344 (F344) rat strain and the Wistar-Kyoto (WKY) strain with its heightened stress-reactivity.
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- The study investigates individual differences in acute stress responsiveness, primarily using Fischer 344 (F344) and Wistar Kyoto (WKY) rat strains known for their contrasting stress behaviors.
- A specific region on chromosome 6, identified as Stresp10, was analyzed for genetic variations that may contribute to these behavioral differences through gene expression studies in key brain areas.
- The creation of a congenic strain combining genetic material from WKY and F344 at the Stresp10 region linked certain genes, like Gpatch11 and Cdkl4, to behavioral traits associated with stress responsiveness, suggesting they may be important in understanding this variation.