Publications by authors named "Jeanette Liao"

Article Synopsis
  • Inflammatory processes are important for understanding type 1 and type 2 diabetes, and a substance called IL-6 is thought to play a big role in both types.
  • Researchers created special mice that produce extra IL-6 in their insulin-producing beta-cells to see how it affects diabetes development.
  • The study found that more IL-6 can lead to high blood sugar and loss of a helpful protein, suggesting that targeting IL-6 could be a good way to help people with diabetes.
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Recent studies have shown that IL-17 can contribute beneficially to pathogen defense but also that excessive IL-17 levels are associated with chronic inflammation and autoimmune disorders. To date, the role of IL-17 in viral infections and type 1 diabetes is ambiguous. In this study, we used IL-17A enhanced green fluorescent protein bicistronic reporter mouse strains to analyze in situ production of IL-17A.

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Redirection of immune responses by manipulation of antigen-presenting cells is an emerging strategy for immunosuppressive treatment of autoimmune diseases. In vivo expansion of dendritic cells (DC) by Fms-like tyrosine kinase-3 (Flt3)-Ligand (FL) treatment was shown to delay diabetes onset in the NOD model of autoimmune diabetes. However, we show here that Flt3 stimulation actually accelerates autoimmunity when autoreactive CD8 T cells are detectable in blood prior to treatment.

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