Uterus transplantation: on the edge.

Uterus transplantation for absolute uterus factor infertility is moving closer to human trials. The indication for uterus transplantation is evident as is its potential to ameliorate the social and personal burdens of these patients. The extensive collaborative research efforts between animal works, advancements in transplantation medicine, and immune suppression have culminated in demonstrating its apparent feasibility.

A pilot safety and tolerability study of a nonhormonal vaginal contraceptive ring.

Objective: To conduct a pilot safety and tolerability study of the Ovaprene ring (Poly-Med Inc., Clemson University, Clemson, South Carolina) as a barrier contraceptive.

Study Design: Open-label, single-arm, observational study in a convenient sample of volunteers.

Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia.

Objective: Standard surgical treatment for CIN may impair fertility generating a need for alternative treatment options. We tested the efficacy and toxicity of oral DIM in the treatment of CIN 2 or 3 lesions.

Methods: Patients with biopsy-proven cervical intraepithelial neoplasia (CIN) 2 or 3 scheduled for loop electrosurgical excision procedure (LEEP) were randomized 2:1 to receive diindolylmethane (DIM) (BioResponse-DIM, BioResponse, Boulder, CO) orally at approximately 2 mg/kg/day for 12 weeks or placebo (defatted rice bran, BioResponse).

Uterus transplant techniques in primates: 10 years' experience.

Preserving and restoring fertility are important quality-of-life outcomes for cancer survivors and others who cannot bear children. Transplantation has advanced sufficiently to allow nonvital organ transplant to become a reality. Together, research on reproductive organs and transplantation has resulted in live human births from ovary transplants used to treat absolute ovary factor infertility.