Asthma Medication Use and Risk of Birth Defects: National Birth Defects Prevention Study, 1997-2011.

Background: Evidence regarding associations between maternal asthma medication use and birth defects is mixed.

Objective: Estimate associations between asthma medciation use and 52 birth defects using National Birth Defects Prevention Study data from 1997 to 2011.

Methods: We compared self-reported maternal asthma medication use for 28,481 birth defect cases and 10,894 nonmalformed controls.

Maternal bronchodilator use and the risk of orofacial clefts.

Background: Few epidemiological studies have explored the relationship between orofacial clefts and bronchodilators. We assessed whether mothers who used bronchodilators during early pregnancy were at an increased risk of delivering infants with orofacial clefts.

Methods: We used National Birth Defects Prevention Study case-control data from mothers of 2711 infants with orofacial clefts and 6482 mothers of live born infants without birth defects, delivered during 1997 through 2005.