Normal and pathological imaging of the hippocampus in geriatric patients.

The hippocampus is a small internal temporal cerebral structure which plays a primordial role in memory mechanisms. Magnetic resonance imaging (MRI) is the preferred method for analysing this structure. In older adults, dementia is the major cause of hippocampal anomalies, particularly atrophic anomalies, however, differential diagnoses involving other specific pathologies should also be recognised in this population.

[Normal and pathological hippocampal imaging in geriatric patients].

The hippocampus is a small internal temporal cerebral structure, which plays a primordial role in the mechanisms of memory. Magnetic resonance imaging (MRI) is the reference imaging modality for the hippocampal analysis. In older adults, dementia represents the majority of hippocampal diseases, but other specific pathologies must be known in the differential diagnosis.

A perceptually relevant channelized joint observer (PCJO) for the detection-localization of parametric signals.

Many numerical observers have been proposed in the framework of task-based approach for medical image quality assessment. However, the existing numerical observers are still limited in diagnostic tasks: the detection task has been largely studied, while the localization task concerning one signal has been little studied and the localization of multiple signals has not been studied yet. In addition, most existing numerical observers need a priori knowledge about all the parameters of the underdetection signals, while only a few of them need at least two signal parameters.

Autologous tumor cell vaccination plus infusion of GM-CSF by a programmable pump in the treatment of recurrent malignant gliomas.

We report on the safety and feasibility of autologous tumor cell vaccination combined with infusion of granulocyte-macrophage colony-stimulating factor by a programmable pump in the treatment of recurrent malignant gliomas. The programmable pump is a promising tool used to infuse cytokines subcutaneously for vaccination. Our trial enrolled nine patients who had undergone surgery, radiation and had been successfully weaned off steroids.

Papilloedema and MRI enhancement of the prechiasmal optic nerve at the acute stage of Leber hereditary optic neuropathy.

The authors report a case of one patient from a family carrying the homoplasmic Leber hereditary optic neuropathy (LHON) G11778A mitochondrial DNA mutation with papilloedema 9 months prior to the acute stage of LHON and still present at the onset of visual loss. During the vision loss, the MRI demonstrated a T2 hyperintensity and an enhancement of the prechiasmal left optic nerve, suggesting the existence of an inflammatory mechanism. A retrospective review of the chart of two others members of the same family, with bilateral optic disc oedema at onset of the vision loss, suggests that the relationship of papilloedema and acute phase of LHON may not be just a coincidence, at least in this family.

Ruptured aneurysm on a double origin of the posterior inferior cerebellar artery: a pathological entity in an anatomical variation. Report of two cases and review of the literature.

The posterior inferior cerebellar artery (PICA) is known to be very variable, and some of its anatomical variations can explain ischemic complications that occur during endovascular treatment of aneurysms. The authors report two cases of anatomical variation of the PICA that they have called its double origin, one of which gave rise to an aneurysm. The first patient was a 36-year-old man who presented with a subarachnoid hemorrhage related to the rupture of a PICA aneurysm.