Publications by authors named "Jean-Pierre Herve"
Article Synopsis
- Dengue is under-researched in Africa, specifically in Cameroon, where a study was conducted to identify factors linked to dengue virus antibodies in individuals across three major cities.
- The study utilized a cross-sectional survey method, gathering data through interviews, blood samples, and environmental assessments to measure seropositivity rates for anti-dengue IgG and IgM antibodies.
- The findings revealed significant seropositivity rates in Douala (61.4%), Garoua (24.2%), and Yaounde (9.8%), with various housing conditions and demographic factors influencing the presence of antibodies, indicating that poverty and underdevelopment play a crucial role in dengue risk.
Article Synopsis
- * This study aimed to assess the immune response (specific IgG antibodies) to Aedes aegypti saliva as a potential indicator of mosquito exposure in urban areas affected by dengue.
- * Findings revealed that younger children had stronger IgG responses to the saliva, which decreased with age, and higher antibody levels correlated with greater mosquito presence, indicating that saliva antibody responses could effectively monitor human exposure to Aedes bites.
Article Synopsis
- Aedes aegypti mosquitoes, originally from Africa, invaded the Americas between the 16th and 18th centuries and later caused outbreaks of yellow fever and dengue.
- After being wiped out from many countries in the mid-20th century, they reappeared in the 1970s and 1980s, particularly in Bolivia, where their genetic origins and population dynamics were studied.
- Research revealed two distinct genetic lineages of Ae. aegypti in Bolivia, with one lineage linked to rural South Bolivia and suggested to have roots in West Africa, influencing local disease patterns of dengue and yellow fever.
Background: The spread of Aedes albopictus, a vector for re-emergent arbovirus diseases like chikungunya and dengue, points up the need for better control strategies and new tools to evaluate transmission risk. Human antibody (Ab) responses to mosquito salivary proteins could represent a reliable biomarker for evaluating human-vector contact and the efficacy of control programs.
Methodology/principal Findings: We used ELISA tests to evaluate specific immunoglobulin G (IgG) responses to salivary gland extracts (SGE) in adults exposed to Aedes albopictus in Reunion Island.
Aedes aegypti (Linné, 1762) is a major vector of arboviruses such as Yellow Fever, Dengue and Chikungunya. In Africa, where the species exhibits major variations in morphology, ecology, behavior and vector competence, two subspecies have been described: a light form, named Ae. aegypti aegypti (Aaa) with highly domestic and anthropophilic habits and a cosmotropical distribution; and a dark form, referred to as Ae.
View Article and Find Full Text PDFSince its discovery in Nigeria in 1991, Aedes albopictus has invaded much of Central Africa, a region where Ae. aegypti also occurs. To assess the relationship between the invasion by Ae.
View Article and Find Full Text PDFDengue fever was first recognized in Bolivia in 1931. However, very limited information was available to date regarding the genetic characterization and epidemiology of Bolivian dengue virus strains. Here, we performed genetic characterization of the full-length envelope gene of 64 Bolivian isolates from 1998 to 2008 and investigated their origin and evolution to determine whether strains circulated simultaneously or alternatively, and whether or not multiple introductions of distinct viral variants had occurred during the period studied.
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- * Significant genetic differentiation was found among sylvan populations (mean F(ST) = 0.066), while domestic populations showed low genetic variability (mean F(ST) = 0.012) and no clear isolation by distance.
- * The mitochondrial DNA analysis indicated higher genetic diversity and recent population growth in the domestic populations, contrasting with the sylvan populations, which displayed a single haplotype, suggesting limited gene flow between the two groups.
People frequently experience whealing and delayed papules from mosquito bites. Various antihistamines have previously been tried for the treatment of this condition. We performed a double-blind, placebo-controlled, cross-over study with levocetirizine 5 mg and matched placebo in 30 adults who were sensitive to mosquito bites.
View Article and Find Full Text PDFThe evaluation of human immune responses to arthropod bites may be a useful marker of exposure to vector-borne diseases, with applications to malaria, the most serious parasitic infection in humans. The specific antibody (Ab) IgG response to saliva obtained from Anopheles gambiae mosquitoes was evaluated in young children from an area of seasonal malaria transmission in Senegal. Specific IgG was higher in children who developed clinical Plasmodium falciparum malaria within the 3 months that followed than in those who did not (P<0.
View Article and Find Full Text PDFThe effectiveness of light-induced killing of mosquito larvae in the presence of photosensitizers was studied with larvae of Aedes aegypti (L.), Anopheles stephensi (Liston), and Culex quinquefasciatus Say grown in the laboratory and of Cx. quinquefasciatus grown under field conditions.
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