Publications by authors named "Jean-Paul Casalta"
Background: Transcatheter aortic valve replacement-related infective endocarditis (TAVR-IE) is associated with a poor prognosis. TAVR-IE diagnosis is challenging, and benefits of the most recent classifications (ESC-2015, ISCVID-2023 and ESC-2023) have not been compared with the conventional Duke criteria on this population.
Objectives: The primary objective was to compare the diagnostic value of the Duke, ESC-2015, ISCVID-2023, and ESC-2023 criteria for the diagnosis of TAVR-IE.
Background: Aortic valve infective endocarditis may be complicated by high-degree atrioventricular block in up to 10-20% of cases.
Aim: To assess high-degree atrioventricular block occurrence, contributing factors, prognosis and evolution in patients referred for aortic infective endocarditis.
Methods: Two hundred and five patients referred for aortic valve infective endocarditis between January 2018 and March 2021 were included in this study.
Article Synopsis
- * Researchers compared two groups of patients—one from the pandemic period and one from the previous year—looking at their clinical outcomes, treatments, and overall management.
- * The findings indicated that the pandemic did not significantly affect the treatment and mortality rates of IE patients, though there was an increase in intravenous drug-related cases, highlighting a potential psychosocial impact of the pandemic.
Multimodality imaging in marantic endocarditis associated with cancer: a multicentric cohort study.
Eur Heart J Cardiovasc Imaging
November 2023
Aims: We aimed to assess the role of multimodality imaging (MMI) in the diagnosis of marantic endocarditis (ME) associated with cancers and to describe the clinical characteristics, management, and outcome of these patients.
Methods And Results: In a retrospective multicentric study including four tertiary centres for the treatment of endocarditis in France and Belgium, patients with a diagnosis of ME were included. Demographic, MMI [echocardiography, computed tomography (CT), and 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT)], and management data were collected.
Clinical and Echocardiographic Features of Patients With Infective Endocarditis and Bicuspid Aortic Valve According to Echocardiographic Definition of Valve Morphology.
J Am Soc Echocardiogr
July 2023
Background: The influence of different bicuspid aortic valve (BAV) morphology in the clinical course of infective endocarditis (IE) has not yet been investigated. This study aimed to describe the clinical and echocardiographic features of IE in patients with BAV (BAVIE) according to valve morphology.
Methods: Patients with definite BAVIE prospectively enrolled in 4 high-volume referral centers from 2000 to 2019 were evaluated and divided into 2 groups according to the echocardiographic definition of fused BAV morphology: right-left coronary (RL type) and right noncoronary or left noncoronary (non-RL type) cusp fusion.
Influence of the healthcare pathway on the outcome of patients with infective endocarditis.
Eur Heart J Acute Cardiovasc Care
September 2022
Article Synopsis
- The study investigates the prognosis of patients with infective endocarditis (IE) based on their healthcare pathway and the application of ESC guidelines in their treatment.
- Conducted in 22 hospitals in South-East France, the research involved 342 patients divided into three groups: those treated entirely in referral centers, those initially treated in non-referral centers then referred, and those entirely treated in non-referral centers.
- Results showed a one-year mortality rate of 26%, with significantly higher mortality (37%) for patients treated solely in non-referral centers compared to those in referral and transferred centers, indicating that healthcare pathway significantly impacts patient outcomes.*
Whipple's disease (WD) is a chronic multisystemic infection caused by . If this bacterium presents an intracellular localization, associated with rare diseases and without pathognomonic signs, it is often subject to a misunderstanding of its physiopathology, often a misdiagnosis or simply an oversight. Here, we report the case of a patient treated for presumed rheumatoid arthritis.
View Article and Find Full Text PDFBackground: We systematically survey respiratory and gastrointestinal infections of viral origin in samples sent to our university hospital institute in Marseille, southern France. Here, we evaluated whether the measures implemented to fight COVID-19 had an effect on the dynamics of viral respiratory or gastrointestinal infections.
Methods: We analysed PCR performed and positive for the diagnoses of viral respiratory and gastrointestinal infections over five years (January 2017-February 2021).
Background: In native mitral valve infective endocarditis (NMIE), the respective values of mitral valve repair (MVRep) and replacement (MVR) are still debated.
Aim: To compare MVRep and MVR in a large prospective matched cohort.
Methods: Between 2010 and 2017, all consecutive patients operated on for NMIE in our centre were included prospectively.
Background: Infective endocarditis (IE) is associated with a high mortality rate, related in part to neurological complications. Studies suggest that valvular surgery should be performed early when indicated, but is often delayed by the presence of neurological complications.
Aim: To assess the effect of delaying surgery in patients with IE and neurological complications and to identify factors predictive of death.
Article Synopsis
- A study involving 275 COVID-19 patients revealed that those with poor clinical outcomes had lower median blood zinc levels compared to those with better outcomes.
- Specifically, patients with poor outcomes had a median zinc level of 840 μg/L, while those with good outcomes had 970 μg/L.
- The significant difference in zinc levels (p < 0.0001) suggests that zinc supplementation might be beneficial for patients experiencing severe COVID-19.
Article Synopsis
- F-FDG PET/CT is now included in the ESC 2015 guidelines for diagnosing infective endocarditis, but its effectiveness in native valve endocarditis (NVE) is not fully understood.
- A study involving 75 patients identified that while F-FDG PET/CT had low sensitivity (17.5%) for diagnosing NVE, it maintained high specificity (100%) and was effective for detecting embolic events.
- The research also revealed a new diagnostic feature of diffuse splenic uptake seen in over half of the patients with NVE, suggesting its potential utility in clinical practice.
The burden of antibiotic resistance is currently estimated by mathematical modeling, without real count of resistance to key antibiotics. Here we report the real rate of resistance to key antibiotics in bacteria isolated from humans during a 5 years period in a large area in southeast in France. We conducted a retrospective study on antibiotic susceptibility of 539,107 clinical strains isolated from hospital and private laboratories in south of France area from January 2014 to January 2019.
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- Fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) is essential for managing infective endocarditis (IE) and detecting cancer.
- Between 2009 and 2018, a study of 750 IE patients showed that 451 underwent PET/CT, leading to incidental cancer diagnoses in 36 patients.
- The highest rates of detected cancers included colorectal, lung, and various others, suggesting PET/CT is highly sensitive and may be useful for cancer screening in IE patients.
Article Synopsis
- The study aimed to evaluate the effectiveness of F-FDG-PET/CT as part of the ESC criteria for diagnosing prosthetic valve infective endocarditis (PVE), while also comparing it to traditional echocardiography.
- Researchers analyzed data from 175 patients suspected of having PVE, ultimately focusing on 115 patients whose F-FDG-PET/CT results were interpretable.
- Results showed that while F-FDG-PET/CT increased the sensitivity of the ESC criteria compared to the Duke criteria, it also decreased specificity, and the presence of diffuse splenic uptake was notable in a significant portion of patients with definitive PVE.
Objective: The primary objective was to assess the characteristics and prognosis of pyogenic spondylodiscitis (PS) in patients with infective endocarditis (IE). The secondary objectives were to assess the factors associated with occurrence of PS.
Methods: Prospective case-control bi-centre study of 1755 patients with definite IE with (n=150) or without (n=1605) PS.
The origin of a cholera outbreak may be unclear, as recently in Algeria. In two patients from North Africa, was isolated in the context of hepatobiliary tract infections without any known outbreak. Gallbladder and asymptomatic long-term carriers might play a role in the emergence of cholera.
View Article and Find Full Text PDFWestern Immunoblotting for the Diagnosis of and Infective Endocarditis.
Front Cell Infect Microbiol
June 2020
Blood culture-negative endocarditis (BCNE) remains a diagnostic challenge. In our center, despite a systematic and exhaustive microbiological diagnostics strategy, 22% of patients with BCNE remain without an identified etiology. In an effort to determine the relevance of using Western blot (WB) for the etiological diagnosis of BCNE in patients with early antibiotic use, we developed specific assays for the major infective endocarditis (IE) causative agents, namely, , and .
View Article and Find Full Text PDFBackground: F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) is commonly used for the diagnosis of infective endocarditis (IE), but its prognostic value remains unknown.
Objectives: This study sought to assess the prognostic value of F-FDG PET/CT in prosthetic valve endocarditis (PVE) and native valve endocarditis (NVE).
Methods: This study prospectively included 173 consecutive patients (109 PVE and 64 NVE) with definite left-sided IE who had an F-FDG PET/CT and were followed-up for 1 year.
Article Synopsis
- The study aimed to assess the effectiveness and safety of a new treatment regimen combining intravenous trimethoprim-sulfamethoxazole and clindamycin (T&C) for Staphylococcus aureus endocarditis compared to traditional treatments.
- It involved 341 patients, with 170 receiving standard treatment before 2012 and 171 receiving the T&C protocol after implementation in 2012.
- Results showed that the T&C group had lower global, in-hospital, and 30-day mortality rates and a significantly shorter average hospital stay compared to the control group.
Article Synopsis
- Intracranial cerebral hemorrhage (ICH) is a significant but poorly understood complication in patients with left-sided infective endocarditis (IE), with a 7% incidence among 963 cases studied from 2000 to 2015.
- The study identified five key risk factors linked to ICH, including low platelet count, severe valve regurgitation, and the presence of mycotic aneurysms, while also classifying ICH mechanisms into three categories: ruptured mycotic aneurysms, hemorrhage after ischemic stroke, and undetermined causes.
- Although overall mortality was not significantly affected by ICH, one-year mortality rates varied by mechanism, and patients who did not undergo surgery had a
Marseille scoring system for empiric treatment of infective endocarditis.
Eur J Clin Microbiol Infect Dis
May 2018
Despite advances in medical, surgical, and critical care, infective endocarditis (IE) remains associated with considerable morbidity and mortality. We evaluated the performance of the Marseille score, including clinical data and biological tests obtained within 2 h, to identify patients at high risk of IE in order to initiate early antimicrobial treatment. This was secondarily confirmed using modified ESC criteria combined with molecular testing and fluorodeoxyglucose-positron emission tomography/computed tomography as diagnostic tools.
View Article and Find Full Text PDFBlood culture-negative endocarditis (BCNE) may represent up to 70% of all endocarditis cases, depending on series. From 2001 to 2009, we implemented in our laboratory a multimodal diagnostic strategy for BCNE that included systematized testing of blood, and when available, valvular biopsy specimens using serological, broad range molecular, and histopathological assays. A causative microorganism was identified in 62.
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