Publications by authors named "Jean-Michel Didelot"
We assessed cumulative detection and determinants of anal high-grade squamous intraepithelial lesions (HSILs) in men who have sex with men living with human immunodeficiency virus and who underwent 3 visits over 2 years, with cytology and high-resolution anoscopy, within the ANRS-EP57-APACHES study. The cumulative HSIL detection rate was 33% (134 of 410), of which 48% HSILs were detected at baseline. HSIL detection varied considerably by center (from 13% to 51%).
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- The study evaluated the long-term effectiveness of hemorrhoidal radiofrequency thermocoagulation (RFT) in reducing symptoms such as bleeding and prolapse, and its impact on quality of life (QoL).
- Out of 124 patients treated, significant improvements were observed, including a reduction in bleeding (from 7 to 3 on a scale of 10) and prolapse (from grade 3 to 2), with over 91% willing to undergo the procedure again.
- While there was a recurrence rate of 21.5% after 22 months, the overall satisfaction was high, and the procedure resulted in low pain and minimal downtime.
Purpose: To describe our experience of radiofrequency thermocoagulation (RFT), assessing patient symptoms and quality of life (QoL) before and after the intervention.
Methods: Between April 2016 and April 2018, 42 outpatients were operated for internal haemorrhoids using RFT. Haemorrhoids were externalised to the anal margin and treated by using the Rafaelo® procedure, using the HPR45i probe (F-Care-Systems) under general anaesthesia.
Incidence and Clearance of Anal Human Papillomavirus (HPV)-16 and HPV-18 Infection, and Their Determinants, Among Human Immunodeficiency Virus-Infected Men Who Have Sex With Men in France.
J Infect Dis
April 2020
Background: Prospective data on the natural history of anal human papillomavirus (HPV) infection are scarce in human immunodeficiency virus (HIV)-infected men who have sex with men (MSM).
Methods: We analyzed incidence and clearance of HPV-16 and HPV-18 in a French cohort of HIV-infected MSM, aged ≥35 years, followed-up annually (n = 438, 2014-2018).
Results: Human papillomavirus-16 and HPV-18 incidence were similar (~10% incident infections at 24 months).
Article Synopsis
- The study investigates anal HPV prevalence and risk factors specifically among HIV-positive men who have sex with men (MSM) aged 35 and older, focusing on their risk of developing anal cancer due to HPV.
- Results show that among 490 participants, 70% were found to have high-risk HPV, with HPV16 being the most common type, especially prevalent in those with severe anal lesions.
- The research highlights that HPV16 is a significant risk factor for high-grade anal lesions in this population, suggesting it should be a primary target for prevention efforts against anal cancer.
Article Synopsis
- The study examined anal samples from 67 HIV-positive men who have sex with men, finding a 74.6% prevalence of anal HPV infection, with 68.7% having high-risk HPV and 56.7% showing multiple HPV types.* ! -
- Commonly detected HPV types included HPV 44/55, HPV 53, HPV 16, HPV 39, and HPV 42, with significant associations found between HPV detection, multiple infections, and cytological abnormalities.* ! -
- The results suggest a high rate of anal high-risk HPV infection and related cytological changes among this population, indicating the potential benefit of HPV testing for identifying patients who may need further examination.* !
Background And Objectives: As perioperative pain management is a difficult challenge during hemorrhoidectomy, we tested the hypothesis that posterior perineal block (PPB) with local anesthetics alone is able to provide adequate pain control during and after surgery.
Methods: In a prospective, blinded, randomized study, we studied analgesic conditions and side effects of PPB in American Society of Anesthesiologists (ASA) I-II patients undergoing hemorrhoidectomy. Patients received general anesthesia (GA) either with PPB (0.