Publications by authors named "Jean-Mathieu L'Orphelin"
Eur Heart J
December 2021
Article Synopsis
- The study aimed to investigate the cardiovascular immune-related adverse events (irAEs) linked to immune checkpoint inhibitors (ICIs) in cancer patients, as the risks and incidence of these events were not well understood.
- Researchers reviewed randomized clinical trials (RCTs) to analyze data on various cardiovascular adverse events (CVAEs), finding that ICI exposure significantly increased the risk of six specific CV irAEs, including myocarditis and dyslipidemia.
- The incidence of these cardiovascular events varied between 3.2 to 19.3 per 1000 patients, emphasizing the need for awareness among healthcare providers regarding these potential risks when using ICIs.
