Changes in first-pass interstitial kinetics of DTPA in myocardium submitted to low-flow ischemia.

Objectives: This study aimed to determine the changes during ischemia in the myocardial first-pass kinetics of DTPA, an extracellular tracer that is currently used for assessing myocardial perfusion with magnetic resonance imaging (Magnevist).

Materials And Methods: Using an indicator-dilution technique, first-pass kinetics of DTPA were compared between normoxia (n=11) and low-flow ischemia (n=11) in isolated rabbit hearts perfused with red blood cell-enhanced perfusate.

Results: There was no difference between ischemia and normoxia in the interstitial extraction and clearance rates of DTPA.