Publications by authors named "Jean-Marc Debonne"
Background: We evaluated the short-term spontaneous fluctuations of HBV DNA and HBsAg levels in Senegalese patients with chronic infection with hepatitis B virus and normal ALT and determined factors related to these fluctuations.
Method: A total of 87 patients with persistent normal ALT values were enrolled in the study. Serum samples were obtained at three different visits, with an interval of 2 months (M0, M2, and M4), and without initiating anti HBV treatment.
Diseases always have a significant impact during military deployments. We evaluated the operational impact of health problems observed in a French infantry battalion (n = 690) during a 4-month assignment in Ivory Coast. In all, 55.
View Article and Find Full Text PDFArticle Synopsis
- Malaria is a significant health issue for travelers and French military personnel deployed to areas where the disease is common, with imported malaria cases increasing, especially among migrants.
- The rise in malaria cases among French soldiers is attributed to factors like incomplete use of preventive medication after returning home and frequent short deployments, with a notable increase in infections from specific malaria types.
- Effective prevention strategies involve choosing the right medication based on local drug resistance, using well-tolerated options like atovaquone-proguanil or doxycycline, and implementing additional measures like bed nets and insect repellents to minimize exposure.
The chemosusceptibility and genetic polymorphism of Plasmodium falciparum populations from 48 patients hospitalized for malaria at the Hospital Principal in Dakar, Senegal were investigated during the 2002 malaria transmission season. Sixty-two percent of the isolates collected were from patients with severe malaria and 38% were from patients with mild malaria. In vitro activities of chloroquine, quinine, cycloguanil, atovaquone, mefloquine, halofantrine, and artesunate were evaluated.
View Article and Find Full Text PDFUsing DNA chip technology and real-time quantitative PCR, molecular profile of HBV strains infecting blood donors and patients in Dakar, Sénégal was studied. All HBsAg-positive blood donors (n = 175) and all patients who presented with chronic hepatitis B (n = 29) between 1st June 2003 and 31st July 2003 were studied. One patient, a blood donor, was coinfected by HCV, and nine patients had anti-HDV antibodies.
View Article and Find Full Text PDFBackground And Purpose: Basic stroke features are hardly known in sub-Saharan countries, and no data are available in Senegal.
Methods: We performed a retrospective hospital-based study in Dakar, Senegal, to assess risk factors and etiology of stroke. Patients were recruited from January 1, 2003, to July 31, 2004, at the Hôpital Principal, Dakar.