Publications by authors named "Jean-Marc Brignon"

Cost-Effectiveness Analysis (CEA) is a decision-making framework to prioritize policy decisions for chemicals. Differences in hazard profiles among chemicals are not integrated in CEA under the EU REACH Regulation, which could limit its relevance. Another concern is that two different economic decision support methods (CEA for chemicals considered as PBTs or vPvBs from a regulatory perspective and Cost Benefit Analysis (CBA) for others) are used under REACH.

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Bis(2-ethylhexyl) phthalate (DEHP) is a plasticizer that has been massively used since the second part of the twentieth century by the plastic industry to provide softness properties to PVC. This chemical is considered as toxic to reproduction and endocrine disrupting, and a wide range of uses are now forbidden by the EU. Despite these regulations, DEHP is still found to be a widespread contaminant in watersheds in the EU.

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Moving towards safe and sustainable innovations is an international policy ambition. In the on-hand manuscript, a concept combining safe by design and sustainability was implemented through the integration of human and environmental risk assessment, life cycle assessment as well as an assessment of the economic viability. The result is a nested and iterative process in form of a decision tree that integrates these three elements in order to achieve sustainable, safe and competitive materials, products or services.

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Reusing materials is an attractive option for circular economy and can also reduce emissions of greenhouse gases and pollutants. However, recycling raises questions regarding the potential risks to human health or the environment when hazardous legacy chemical additives of materials are also recycled, instead of the recent and less hazardous additives of virgin materials. To address this trade-off, this study developed a model to calculate the total external cost of material supply, considering the health and environmental impacts of all industrial steps (e.

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