Publications by authors named "Jean-Luc Dimicoli"

This paper presents a model describing the diffusion of water and contrast agent (CA) in hollow fibre modules (HFM), which is able to calculate the contribution of water molecular exchange to the parameters resulting from dynamic R(1) relaxation data. To acquire these data, the intra-fibre volume of the HFM initially filled with pure water was perfused with a CA solution of constant concentration C(0). The relaxation rate R(1e)(t) time course was measured assuming fast water molecular exchange, with a saturation-recovery multi-gradient-echo snapshot sequence.

View Article and Find Full Text PDF

A double-delay SR-MGE-SNAP sequence allowing simultaneous T1 and T2* measurement was developed for integrating arterial input function (AIF) measurement into DCE MRI. Implemented on a 4.7-T animal MR system, this technique was applied to mice with colorectal tumor xenografts.

View Article and Find Full Text PDF

This paper describes multinuclear NMR investigations on the isolated perfused mouse liver to optimize its recovery after cold preservation and normothermic reperfusion. The recovery of livers from fed is better than that from 24 h fasted animals. This better recovery is not due to a higher glycogen content before cold preservation.

View Article and Find Full Text PDF

We present experimental MRI protocols at 4.7 T for quantitative determination of the Dotarem distribution volume in isolated perfused rat liver. The procedures involved either constant contrast agent (CA) concentration or bolus administration conditions.

View Article and Find Full Text PDF

Background: The deleterious effect of steatosis on transplanted livers is mainly related to a microcirculation impairment. We investigated the effect of preservation duration on the recovery of isolated perfused rat steatotic livers and tested the effect of pentoxifylline (PTX), known to have a beneficial effect on hepatic microcirculation.

Materials And Methods: Fatty rat livers were obtained using a diet able to induce an 80% to 100% microvesicular steatosis within 7 days.

View Article and Find Full Text PDF

The effect of donor nutritional status on hepatic function recovery after cold ischemia is still debated. We demonstrated previously that a 48-h fast diminished the survival rate of liver-transplanted rats and that the deleterious effect of fasting was prevented by infusion of alanine to the recipient at reperfusion. Whether the duration of fasting influenced the protective effect of alanine and whether this effect was metabolic were not known, and the elucidation of these questions is the aim of this study.

View Article and Find Full Text PDF