Publications by authors named "Jean-Louis Preud'homme"
Article Synopsis
- BDNF (Brain-derived neurotrophic factor) acts as a growth factor and has been found to have an antiapoptotic effect, particularly in myeloma cells, and its secretion can be influenced by stress conditions.
- The study revealed that B cells can produce sortilin, a transport protein for BDNF, which plays a key role in the production and survival functions of BDNF under stress culture conditions.
- Increased BDNF production in mature B cell lines is linked to autocrine signaling and is important for understanding drug resistance in malignant B cells, while normal B cells also utilize sortilin and BDNF for survival and activation.
In human African trypanosomiasis, trypanosomes first develop in the blood and lymph (Stage 1), then spread to the central nervous system (CNS) (Stage 2). Disruption of the blood-brain barrier of unknown mechanism occurs in Stage 2 disease. The hypothesis that cerebrospinal fluids (CSF) from African trypanosomiasis patients might contain factor(s) able to induce apoptosis in endothelial cells led us to evaluate this effect by two methods, the TdT-mediated dUTP nick end labelling (TUNEL) method and the measurement of soluble nucleosomes released by apoptotic cells in culture supernatant by ELISA.
View Article and Find Full Text PDFArticle Synopsis
- The study examines two types of glomerulonephritis (GN) characterized by organized immunoglobulin deposits: fibrillary GN (FGN) and immunotactoid GN (IT/MTGN), focusing on their ultrastructural differences and clinical relevance.
- Out of 23 patients analyzed, both groups displayed similar clinical symptoms and deposit characteristics, but IT/MTGN was linked to associated monoclonal gammopathy or B-cell lymphoproliferative disease.
- Although long-term renal outcomes were comparable, chemotherapy was effective in achieving remission of nephrotic syndrome in IT/MTGN patients, indicating differences in treatment response between the two types.