Publications by authors named "Jean-Louis Kuntz"
Hepatitis C-associated osteosclerosis (HCAO) is characterized by increased bone mass following hepatitis C infection. We report here a case of HCAO that lasted 8 years before the patient received antiviral hepatitis treatment. Seven years after the antiviral treatment, the evolution of radiographs and densitometry showed skeletal recovery of osteosclerosis.
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- Rheumatoid arthritis (RA) is a chronic joint disease that can lead to serious cardiovascular issues, primarily due to the presence of atheroma.
- A case study of a 46-year-old RA patient revealed elevated homocysteine levels due to a specific genetic mutation, despite her not having traditional cardiovascular risk factors.
- Hyperhomocysteinemia, which affects 20%-42% of RA patients, can contribute to arterial and venous diseases, but can be managed effectively with folic acid supplementation.
Article Synopsis
- Vertebral osteonecrosis typically shows an intravertebral vacuum cleft on MR images, seen in older patients with severe fractures and instability, but these clefts may indicate fracture non-union rather than being specific to osteonecrosis.
- The double-line sign is commonly associated with osteonecrosis in long bones, although it has been observed in a rare case involving spinal cord and vertebral bone marrow radionecrosis.
- The case presented discusses a confirmed multilevel vertebral osteonecrosis exhibiting the double-line sign without vertebral collapse or relation to prior radiotherapy.
Objective: To investigate the safety of infliximab (INF) combination therapy with leflunomide (LEF) or azathioprine (AZA) in patients with rheumatoid arthritis (RA).
Method: A standardized questionnaire on the use of INF in combination with LEF or AZA was mailed to hospital physicians and collected over a 2 month period. Adverse events (AE) and the reasons for withdrawal of combination therapy were analyzed.
Bone and joint infections due to Streptococcus pneumoniae are uncommon in adults in the absence of risk factors (e.g. alcohol abuse, immunodepression, or preexisting joint disease).
View Article and Find Full Text PDFWe report four cases of sciatica in patients with same-level disk herniation confirmed by computed tomography and a final diagnosis of acute radiculitis caused by Borrelia burgdorferi, with a favorable response to ceftriaxone therapy. The neurological manifestations of Lyme disease are protean, and a potential contribution of concomitant disk disease to sciatica can lead to diagnostic wanderings. Disk lesions and infectious conditions that can cause sciatica are discussed.
View Article and Find Full Text PDFOccupational bone diseases are uncommon, with fewer than 400 cases recognized in France since 1990, although many cases have escaped diagnosis. The symptoms lack specificity, raising diagnostic challenges. Greater awareness of these conditions and of their pathophysiological mechanisms would provide much needed improvement in diagnosis and prevention.
View Article and Find Full Text PDFBackground: The management of common low back pain has two principal objectives: to relieve acute pain and to attempt prevention of transition to chronicity. Several studies have shown the ineffectiveness of prolonged periods of bed rest.
Objective: To compare 4 days of bed rest with continued normal daily activity in acute low back pain, taking into account the type of work (physical or sedentary labor).