Publications by authors named "Jean-L Pasquali"
The phenotypic characterization of self-reactive B cells producing autoantibodies is one of the challenges to get further insight in the physiopathology of autoimmune diseases. We took advantage of our previously developed flow cytometry method, using labeled nucleosomes, prominent autoantigens in systemic lupus erythematosus, to analyze the phenotype of self-reactive B cells in the anti-DNA B6.56R mouse model.
View Article and Find Full Text PDFThe pathogenesis of autoimmune diseases has not been completely elucidated yet, and only a few specific treatments have been developed so far. In autoimmune diseases mediated by pathogenic autoantibodies, such as systemic lupus erythematosus, the specific detection and analysis of autoreactive B cells is crucial for a better understanding of the physiopathology. Biological characterization of these cells may help to define new therapeutic targets.
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- * The unique polyreactivity of NAbs is attributed to the complementarity determining region 3 (CDR3) of their heavy chains, suggesting a positive selection of these B cells from the immune system's pre-existing pool.
- * Research indicates that some infections can activate NAb-producing B cells driven by autoantigens, but there is still no direct evidence that this leads to harmful autoAbs, raising questions about the true source of these pathogenic antibodies.