Publications by authors named "Jean-Jacques Von Hunolstein"
Introduction: Transthyretin cardiac amyloidosis is a pathology increasingly encountered in all hospital departments, including internal medicine. The aim of our study is to describe the characteristics and care pathway of patients with transthyretin cardiac amyloidosis in internal medicine and to show that the number of patients diagnosed is increasing.
Methods: Descriptive, retrospective, non-interventional, single-center study at Strasbourg University Hospitals (HUS).
Introduction: Colchicine, commonly used in gout flare, is contraindicated in severe chronic kidney disease (CKD) (estimated glomerular filtration rate <30 mL/min). However, in this context, there are few alternatives, and colchicine use persists. We evaluated the tolerance of colchicine and its efficacy in patients with severe CKD.
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- Acute pulmonary embolism (APE) frequently occurs in COVID-19 patients and leads to worse health outcomes, highlighting a potential link between inflammation and blood clotting issues in COVID-19.
- The study reviewed data from patients with APE at Strasbourg University Hospital, comparing those with COVID-19 to those without, focusing on their clinical and biological markers during hospitalization.
- Results showed that COVID-19 patients had a significantly higher severity index and were more often transferred to the ICU, indicating a specific and severe profile associated with APE in the context of COVID-19 infections.
The Coronavirus Disease 2019 (COVID-19) pandemic exposed health professionals to high stress levels inducing significant psychological impact. Our region, , was the most impacted French region during the first COVID-19 wave. In this context, we created CoviPsyHUS, local mental health prevention and care system dedicated explicitly to healthcare workers affected by the COVID-19 pandemic in one of this region's tertiary hospitals.
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- The study aimed to distinguish between Takotsubo syndrome (TTS) and two types of myocardial infarction (STEMI and NSTEMI) using cardiac biomarkers.
- Researchers analyzed data from 1100 patients and found that the BNP/TnI ratio was effective in differentiating between these conditions.
- A scoring system incorporating clinical and biomarker data showed high sensitivity and specificity for identifying TTS compared to STEMI and NSTEMI.
Article Synopsis
- - A 71-year-old woman with a mild case of SARS-CoV-2 had acute myopericarditis diagnosed through various medical tests.
- - This case emphasizes that cardiac issues can occur even without severe COVID-19 symptoms.
- - The exact causes of heart injury from SARS-CoV-2 are unclear and more research is needed to understand if it’s due to direct viral damage or other systemic factors.
Article Synopsis
- VTE is a common issue among patients with COVID-19, affecting 17.0% of those studied in a single-center research.
- The study found that not using thromboprophylaxis and having high white blood cell counts (leukocytosis) are significant risk factors for developing VTE.
- Additionally, VTE is linked to poorer results during the patients' hospital stays.
Article Synopsis
- * RVF occurred in 32 patients (47.1%), with significant predictors being high preoperative vasoactive inotropic scores and serum glutamic oxaloacetic transaminase levels, while a thoracotomy approach significantly lowered RVF risk.
- * Mortality rates were high, with 53.1% in the RVF group vs. 5.6% in controls, and one-year survival rates were significantly better for the non-RVF group (85.4% vs. 33.5%).
Article Synopsis
- The study aimed to assess the effectiveness of the PRADO-IC program in reducing re-hospitalizations due to chronic heart failure (HF) among patients in the Bas-Rhin region of France.
- It included 91 patients aged around 79 years, evaluating their hospital readmissions at intervals of 30 days, 6 months, and 1 year post-enrollment in the program.
- The results indicated a significant decrease in both the frequency of HF-related hospitalizations and the average length of stay, suggesting that the PRADO-IC program successfully improved patient outcomes.
Reactive oxygen species (ROS) are central bioenergetic markers linked to aortic stenosis (AS) development and severity. We sought to evaluate the time course and impact of ROS assessed by plasmatic superoxide anion (SA) among patients undergoing transcatheter aortic valve replacement (TAVR). Among 106 patients, SA significantly decreased after TAVR.
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- Epicardial adipose tissues (EATs) and vascular tissues develop from epicardium-derived progenitor cells (EPDCs) in the heart, but their molecular mechanisms are not well understood, especially in adults.
- This study investigates the role of the angiogenic hormone prokineticin-2 (PK2) in controlling stem cell properties and promoting blood vessel formation from human EPDCs, revealing that PK2 influences cellular transformation and division.
- The research highlights how PK2, through the histone demethylase KDM6A, regulates gene expression to enhance vascular lineage commitment while reducing adipogenic tendencies, presenting potential targets for therapies in heart diseases.
Article Synopsis
- Paravalvular aortic regurgitation (PVAR) is a common issue after transcatheter aortic valve replacement (TAVR), linked to complications like bleeding due to altered blood flow dynamics.
- This study found that an increase in closure time with adenosine diphosphate (CT-ADP) post-procedure can indicate significant PVAR and potential bleeding risks at 30 days follow-up.
- Specifically, a CT-ADP measurement over 180 seconds was shown to be an independent predictor of both significant PVAR and major/life-threatening bleeding complications in patients.
Can prokineticin prevent obesity and insulin resistance?
Curr Opin Endocrinol Diabetes Obes
October 2015
Article Synopsis
- Obesity is a growing health issue caused by excessive calorie intake and low physical activity, influenced by genetic factors and metabolic disorders like insulin resistance.* -
- Prokineticins, a newly discovered group of adipokines, are linked to obesity and insulin resistance, primarily acting through receptors PKR1 and PKR2.* -
- This review highlights how prokineticins can control food intake in the brain and enhance insulin sensitivity while inhibiting fat growth, suggesting their receptors could be new targets for treating obesity.*